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MFSD14B major facilitator superfamily domain containing 14B [ Homo sapiens (human) ]

Gene ID: 84641, updated on 2-Nov-2024

Summary

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Official Symbol
MFSD14Bprovided by HGNC
Official Full Name
major facilitator superfamily domain containing 14Bprovided by HGNC
Primary source
HGNC:HGNC:23376
See related
Ensembl:ENSG00000148110 MIM:620348; AllianceGenome:HGNC:23376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIATL1
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in esophagus (RPKM 21.3), lung (RPKM 18.5) and 25 other tissues See more
Orthologs
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Genomic context

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See MFSD14B in Genome Data Viewer
Location:
9q22.32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (94374417..94461042)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (106544066..106630677)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97136851..97223324)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100132077 Neighboring gene proline-rich nuclear receptor coactivator 2-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97103095-97103595 Neighboring gene prothymosin alpha pseudogene 12 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:97136619-97137120 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:97137121-97137620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28631 Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing pseudogene 1 Neighboring gene MPRA-validated peak7296 silencer Neighboring gene uncharacterized LOC107987100 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110230 Neighboring gene MPRA-validated peak7297 silencer Neighboring gene leishmanolysin like peptidase pseudogene Neighboring gene RNA, U6 small nuclear 669, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110244 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110264 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110288 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110294 Neighboring gene uncharacterized LOC124902218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97315577-97316239 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97316904-97317566 Neighboring gene prostate cancer associated transcript 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer. Gong J, et al. PLoS Genet, 2016 Oct. PMID 27723779, Free PMC Article
  2. A protein interaction framework for human mRNA degradation. Lehner B, et al. Genome Res, 2004 Jul. PMID 15231747, Free PMC Article
  3. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14753, MGC117350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hippocampus abundant transcript-like protein 1
Names
hippocampus abundant transcript-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032558.3 → NP_115947.2  hippocampus abundant transcript-like protein 1

    See identical proteins and their annotated locations for NP_115947.2

    Status: VALIDATED

    Source sequence(s)
    AL358232, BC106062, BU507687, BX359483
    Consensus CDS
    CCDS6710.2
    UniProtKB/Swiss-Prot
    B4DUE6, E9PD58, Q3KQT4, Q53GU5, Q5SR56, Q8WU95, Q96SM4
    Related
    ENSP00000364493.3, ENST00000375344.8
    Conserved Domains (2) summary
    cd06174
    Location:48 → 450
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:49 → 394
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    94374417..94461042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015218.2 → XP_016870707.1  hippocampus abundant transcript-like protein 1 isoform X4

    Conserved Domains (2) summary
    cd06174
    Location:18 → 385
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:18 → 329
    MFS_1; Major Facilitator Superfamily

  2. XM_017015219.3 → XP_016870708.1  hippocampus abundant transcript-like protein 1 isoform X1

  3. XM_047423972.1 → XP_047279928.1  hippocampus abundant transcript-like protein 1 isoform X2

  4. XM_047423973.1 → XP_047279929.1  hippocampus abundant transcript-like protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    106544066..106630677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364016.1 → XP_054219991.1  hippocampus abundant transcript-like protein 1 isoform X4

  2. XM_054364013.1 → XP_054219988.1  hippocampus abundant transcript-like protein 1 isoform X1

  3. XM_054364014.1 → XP_054219989.1  hippocampus abundant transcript-like protein 1 isoform X2

  4. XM_054364015.1 → XP_054219990.1  hippocampus abundant transcript-like protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SR56.3 GenPept UniProtKB/Swiss-Prot:Q5SR56

Gene LinkOut

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