TRIM55 tripartite motif containing 55 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM55provided by HGNC
Official Full Name: tripartite motif containing 55provided by HGNC
Primary source: HGNC:HGNC:14215
See related: Ensembl:ENSG00000147573 MIM:606469; AllianceGenome:HGNC:14215
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNF29; muRF2; MURF-2
Summary: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in heart (RPKM 14.3), liver (RPKM 6.5) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q13.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (66113351..66175485)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (66538238..66601172)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (67039364..67087720)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMO-3 promotes the ubiquitin-dependent turnover of TRIM55.
Title: SUMO-3 promotes the ubiquitin-dependent turnover of TRIM55.
TRIM55 inhibits colorectal cancer development via enhancing protein degradation of c-Myc.
Title: TRIM55 inhibits colorectal cancer development via enhancing protein degradation of c-Myc.
Genetic and functional implications of an exonic TRIM55 variant in heart failure.
Title: Genetic and functional implications of an exonic TRIM55 variant in heart failure.
Overexpression of TRIM55 was associated with lower cell migration and invasion ability, and it led to high expression of E-cadherin and low expression of Vimentin and MMP2.
Title: Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2).
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of tripartite motif containing 55 (TRIM55) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed
Knockdown of tripartite motif containing 55 (TRIM55) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93236 (e-PCR)
- UniSTS:92771

GDB:196438 (e-PCR)
- UniSTS:155849

RH103463 (e-PCR)
- UniSTS:97788

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diapedesis	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte migration involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in macrophage migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in microtubule	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tripartite motif-containing protein 55

Names: muscle specific ring finger 2; muscle-specific RING finger protein 2; ring finger protein 29

NP_149047.2

EC 2.3.2.27

NP_908973.1

EC 2.3.2.27

NP_908974.1

EC 2.3.2.27

NP_908975.1

EC 2.3.2.27

XP_005251373.1

EC 2.3.2.27

XP_011515919.1

EC 2.3.2.27

XP_016869397.1

EC 2.3.2.27

XP_024303076.1

EC 2.3.2.27

XP_054217335.1

EC 2.3.2.27

XP_054217336.1

EC 2.3.2.27

XP_054217337.1

EC 2.3.2.27

XP_054217338.1

EC 2.3.2.27

XP_054217339.1

EC 2.3.2.27

XP_054217340.1

EC 2.3.2.27

XP_054217341.1

EC 2.3.2.27

XP_054217342.1

EC 2.3.2.27

XP_054217343.1

EC 2.3.2.27

XP_054217344.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033058.3 → NP_149047.2 tripartite motif-containing protein 55 isoform 2

See identical proteins and their annotated locations for NP_149047.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an additional exon within the coding region compared to variant 1, which causes a frameshift. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AJ431704, AK091310

Consensus CDS

CCDS6187.1

UniProtKB/Swiss-Prot

Q9BYV6

Related

ENSP00000276573.7, ENST00000276573.11

Conserved Domains (3) summary

cd00162
Location:26 → 85

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00643
Location:119 → 161

zf-B_box; B-box zinc finger

cl23765
Location:168 → 294

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_184085.2 → NP_908973.1 tripartite motif-containing protein 55 isoform 1

See identical proteins and their annotated locations for NP_908973.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AJ291712, AK091310

Consensus CDS

CCDS6184.1

UniProtKB/Swiss-Prot

B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6

Related

ENSP00000323913.4, ENST00000315962.9

Conserved Domains (3) summary

cd00162
Location:26 → 85

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00643
Location:119 → 161

zf-B_box; B-box zinc finger

cl23765
Location:168 → 294

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_184086.2 → NP_908974.1 tripartite motif-containing protein 55 isoform 3

See identical proteins and their annotated locations for NP_908974.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon within the coding region compared to variant 1. The resulting isoform (3) lacks an internal region, as compared to isoform 1.

Source sequence(s)

AK091310

Consensus CDS

CCDS6185.1

UniProtKB/Swiss-Prot

Q9BYV6

Related

ENSP00000297348.8, ENST00000353317.9

Conserved Domains (3) summary

pfam00643
Location:119 → 161

zf-B_box; B-box zinc finger

cd16760
Location:21 → 84

RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins

cl25407
Location:168 → 294

ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
NM_184087.2 → NP_908975.1 tripartite motif-containing protein 55 isoform 4

See identical proteins and their annotated locations for NP_908975.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks four exons within the coding region compared to variant 1. The translation frame remains the same. The resulting isoform (4) lacks an internal region, as compared to isoform 1. This isoform (4) was detected specifically in cardiac muscle.

Source sequence(s)

AJ277493, AK091310

Consensus CDS

CCDS6186.1

UniProtKB/Swiss-Prot

Q9BYV6

Related

ENSP00000332302.4, ENST00000350034.4

Conserved Domains (2) summary

cd16760
Location:21 → 84

RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins

cl00034
Location:122 → 166

Bbox_SF; B-box-type zinc finger superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

66113351..66175485

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011517617.3 → XP_011515919.1 tripartite motif-containing protein 55 isoform X4

Conserved Domains (2) summary

pfam00643
Location:1 → 39

zf-B_box; B-box zinc finger

cl23765
Location:46 → 172

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_017013908.2 → XP_016869397.1 tripartite motif-containing protein 55 isoform X2
XM_005251316.5 → XP_005251373.1 tripartite motif-containing protein 55 isoform X1

Conserved Domains (3) summary

cd00162
Location:26 → 85

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00643
Location:119 → 161

zf-B_box; B-box zinc finger

cl23765
Location:168 → 294

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_024447308.1 → XP_024303076.1 tripartite motif-containing protein 55 isoform X3

Conserved Domains (3) summary

pfam00643
Location:119 → 161

zf-B_box; B-box zinc finger

cd16760
Location:21 → 84

RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins

cl25407
Location:168 → 294

ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)