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TRIM63 tripartite motif containing 63 [ Homo sapiens (human) ]

Gene ID: 84676, updated on 18-Sep-2024

Summary

Official Symbol
TRIM63provided by HGNC
Official Full Name
tripartite motif containing 63provided by HGNC
Primary source
HGNC:HGNC:16007
See related
Ensembl:ENSG00000158022 MIM:606131; AllianceGenome:HGNC:16007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRF; SMRZ; MURF1; MURF2; RNF28
Summary
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
Expression
Biased expression in heart (RPKM 44.7) and esophagus (RPKM 2.8) See more
Orthologs
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Genomic context

See TRIM63 in Genome Data Viewer
Location:
1p36.11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26051301..26067630, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25888705..25905036, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26377792..26394121, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26371640-26372208 Neighboring gene solute carrier family 30 member 2 Neighboring gene uncharacterized LOC105376910 Neighboring gene Sharpr-MPRA regulatory region 4919 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26405707-26405883 Neighboring gene VISTA enhancer hs2271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 473 Neighboring gene PDLIM1 interacting kinase 1 like Neighboring gene Sharpr-MPRA regulatory region 12487 Neighboring gene Sharpr-MPRA regulatory region 4586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26480925-26481654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26481655-26482384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26482385-26483114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26483115-26483844 Neighboring gene family with sequence similarity 110 member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ32380

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables titin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in response to electrical stimulus involved in regulation of muscle adaptation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in skeletal muscle atrophy IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in M band IEA
Inferred from Electronic Annotation
more info
 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in microtubule NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM63
Names
RING-type E3 ubiquitin transferase TRIM63
iris ring finger protein
muscle specific ring finger protein 2
muscle-specific RING finger protein 1
ring finger protein 28
striated muscle RING zinc finger protein
tripartite motif containing 63, E3 ubiquitin protein ligase
tripartite motif-containing protein 63
NP_115977.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033268.1 RefSeqGene

    Range
    5001..21331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_757

mRNA and Protein(s)

  1. NM_032588.4NP_115977.2  E3 ubiquitin-protein ligase TRIM63

    See identical proteins and their annotated locations for NP_115977.2

    Status: REVIEWED

    Source sequence(s)
    AI351421, AL391650, BC080529, DA900348
    Consensus CDS
    CCDS273.1
    UniProtKB/Swiss-Prot
    B4DN95, Q5T2I1, Q969Q1, Q96BD3, Q96KD9, Q9BYV4
    UniProtKB/TrEMBL
    Q6NR77
    Related
    ENSP00000363390.3, ENST00000374272.4
    Conserved Domains (3) summary
    smart00336
    Location:120159
    BBOX; B-Box-type zinc finger
    cd00162
    Location:2382
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:188283
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26051301..26067630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    25888705..25905036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)