TXNDC17 thioredoxin domain containing 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TXNDC17provided by HGNC
Official Full Name: thioredoxin domain containing 17provided by HGNC
Primary source: HGNC:HGNC:28218
See related: Ensembl:ENSG00000129235 MIM:616967; AllianceGenome:HGNC:28218
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRP14; TXNL5
Summary: Enables peroxidase activity and protein-disulfide reductase (NAD(P)H) activity. Involved in tumor necrosis factor-mediated signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon (RPKM 14.3), esophagus (RPKM 13.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (6641060..6644541)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (6541691..6545172)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (6544380..6547861)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In-Depth Proteomic Analysis of Paraffin-Embedded Tissue Samples from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1 as Key Proteins Associated with the Disease.
Title: In-Depth Proteomic Analysis of Paraffin-Embedded Tissue Samples from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1 as Key Proteins Associated with the Disease.
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.
Title: TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.
Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.
Title: Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.
TXNDC17, through participation of BECN1, induces autophagy and consequently results in paclitaxel resistance in ovarian cancer
Title: TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.
The oxidoreductase activities of TRP14 thereby complement those of Trx1 and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols.
Title: Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
LC8 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state.
Title: Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.
TRP14 is a thioredoxin-related protein of 14 kDa
Title: Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function.
TRP14 is a thioredoxin-related protein with roles in tumor necrosis factor-alpha signaling pathways
Title: Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.
Data report the crystal structure of human thioredoxin-related protein 14 determined at 1.8-angstrom resolution.
Title: Structural basis of cellular redox regulation by human TRP14.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH64650 (e-PCR)
- UniSTS:53528

TXNL5__5171 (e-PCR)
- UniSTS:466540

SHGC-32950 (e-PCR)
- UniSTS:35204

RH91775 (e-PCR)
- UniSTS:83879

STS-N30572 (e-PCR)
- UniSTS:36009

D17S1392E (e-PCR)
- UniSTS:150443

RH47146 (e-PCR)
- UniSTS:57535

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-disulfide reductase (NAD(P)H) activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase (NAD(P)H) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: thioredoxin domain-containing protein 17

Names: 14 kDa thioredoxin-related protein; protein 42-9-9; testicular tissue protein Li 214; thioredoxin (Trx)-related protein, 14 kDa; thioredoxin-like 5; thioredoxin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032731.4 → NP_116120.1 thioredoxin domain-containing protein 17

See identical proteins and their annotated locations for NP_116120.1

Status: VALIDATED

Source sequence(s)

AC004706, BC006405

Consensus CDS

CCDS11077.1

UniProtKB/Swiss-Prot

A8K7E8, Q9BRA2

UniProtKB/TrEMBL

A0A140VJY7

Related

ENSP00000250101.5, ENST00000250101.10

Conserved Domains (1) summary

cd02952
Location:4 → 121

TRP14_like; Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. ...