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PPFIA1 PTPRF interacting protein alpha 1 [ Homo sapiens (human) ]

Gene ID: 8500, updated on 7-Apr-2024

Summary

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Official Symbol
PPFIA1provided by HGNC
Official Full Name
PTPRF interacting protein alpha 1provided by HGNC
Primary source
HGNC:HGNC:9245
See related
Ensembl:ENSG00000131626 MIM:611054; AllianceGenome:HGNC:9245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIP1; LIP.1; LIPRIN
Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.0), thyroid (RPKM 12.7) and 25 other tissues See more
Orthologs
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Genomic context

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See PPFIA1 in Genome Data Viewer
Location:
11q13.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (70270690..70384396)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (70285642..70404818)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70116796..70230502)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3699 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70049941-70050132 Neighboring gene uncharacterized LOC124902705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70058905-70059714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70059715-70060524 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70060525-70061332 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:70065875-70066575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:70075454-70075954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3701 Neighboring gene uncharacterized LOC107984346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70148375-70148874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70157785-70158680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70158681-70159574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:70156675-70157176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70159641-70160157 Neighboring gene Fas associated via death domain Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70166538-70166719 Neighboring gene uncharacterized LOC105369373 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70175478-70175614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70187532-70188110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70188111-70188688 Neighboring gene microRNA 548k Neighboring gene H2A.Z histone pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70230466-70230972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:70235067-70235838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70235839-70236608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70237380-70238149 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70242965-70243153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3703 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3704 Neighboring gene Sharpr-MPRA regulatory region 1776 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70250285-70250464 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70261331-70261532 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:70265651-70266850 Neighboring gene CTTN divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70289993-70290826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70343973-70344473 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70346781-70346940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70351607-70352106 Neighboring gene cortactin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70364325-70364826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70369495-70370452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70370453-70371408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70371409-70372366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70373323-70374279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70385241-70385858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70384621-70385240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70390839-70391673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70392509-70393343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70393780-70394730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70397475-70397990 Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:70399135-70400334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70403420-70404150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70404151-70404881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70423187-70423687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70422686-70423186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70425215-70425716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70428716-70429218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70429219-70429720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70429721-70430223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70430775-70431315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70457727-70458490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70464553-70465368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70465369-70466183 Neighboring gene SHANK2 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis. Gao Y, et al. BMC Cancer, 2023 May 9. PMID 37158817, Free PMC Article
  2. Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC). Blessmann M, et al. J Craniomaxillofac Surg, 2013 Dec. PMID 23453270
  3. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. Christie JD, et al. PLoS One, 2012. PMID 22295056, Free PMC Article
  4. Liprin-alpha1 promotes cell spreading on the extracellular matrix by affecting the distribution of activated integrins. Asperti C, et al. J Cell Sci, 2009 Sep 15. PMID 19690048
  5. Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma. Tan KD, et al. Genes Chromosomes Cancer, 2008 Apr. PMID 18196592

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Liprin-alpha1 contributes to oncogenic MAPK signaling by counteracting ERK activity.
    Title: Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity.
  2. High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.
    Title: High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.
  3. Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
    Title: Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
  4. Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.
    Title: Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.
  5. We found that PPFIA1 and ALG3 were distinctively overexpressed at the mRNA level in HNSCC tissues compared with normal tissues, they had a significant co-occurrence relationship. Patients without both PPFIA1 and ALG3 mRNA expression alterations had better overall survival and disease/progression-free survival compared with patients with both PPFIA1 and ALG3 alterations.
    Title: Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma.
  6. liprin-alpha1 as a novel regulator of CD82
    Title: Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.
  7. The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility.
    Title: Identification of a membrane-less compartment regulating invadosome function and motility.
  8. This study shows that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo.
    Title: PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis.
  9. Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor+/N- breast cancer, but not in estrogen receptor+/N+ or estrogen receptor- patients.
    Title: PPFIA1 is upregulated in liver metastasis of breast cancer and is a potential poor prognostic indicator of metastatic relapse.
  10. These results indicate that liprin-alpha1 localizes to different adhesion and cytoskeletal structures to regulate vimentin intermediate filament network, thereby altering the invasion and growth properties of the cancer cells.
    Title: Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with PFFIA1 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41337, FLJ42630, FLJ43474, MGC26800

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-matrix adhesion TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic active zone TAS
Traceable Author Statement
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
located_in spine apparatus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
liprin-alpha-1
Names
LAR-interacting protein 1
LIP-1
Liprin-alpha1
protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378006.1 → NP_001364935.1  liprin-alpha-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP000487, AP002336, KC877433
    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (5) summary
    cd09562
    Location:910 → 980
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1027 → 1092
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1112 → 1183
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:246 → 546
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:45 → 687
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_003626.5 → NP_003617.1  liprin-alpha-1 isoform b

    See identical proteins and their annotated locations for NP_003617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and it encodes the longer protein (isoform b).
    Source sequence(s)
    AP000487, AP002336, KC877433
    Consensus CDS
    CCDS31627.1
    UniProtKB/Swiss-Prot
    A6NLE3, Q13135, Q13136, Q14567, Q8N4I2
    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Related
    ENSP00000253925.7, ENST00000253925.12
    Conserved Domains (6) summary
    cd09562
    Location:875 → 945
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:962 → 1027
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1047 → 1118
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1048 → 1118
    SAM; Sterile alpha motif
    pfam12795
    Location:321 → 517
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 445
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_177423.3 → NP_803172.1  liprin-alpha-1 isoform a

    See identical proteins and their annotated locations for NP_803172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' end, which includes a part of the coding region and 3' UTR, as compared to variant 2. The resulting protein (isoform a) has a distinct and shorter C-terminus, as compared to isoform b.
    Source sequence(s)
    AP000487, AP002336, KC877433
    Consensus CDS
    CCDS31628.1
    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Related
    ENSP00000374198.3, ENST00000389547.7
    Conserved Domains (6) summary
    cd09562
    Location:875 → 945
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:962 → 1027
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1047 → 1118
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1048 → 1118
    SAM; Sterile alpha motif
    pfam12795
    Location:321 → 517
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 445
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. NR_045286.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in an internal exon and contains an alternate exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000487, AP002336, KC877433
    Related
    ENST00000532504.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    70270690..70384396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718716.4 → XP_006718779.1  liprin-alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_006718779.1

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (7) summary
    cd09562
    Location:949 → 1019
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1066 → 1131
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1151 → 1222
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1152 → 1222
    SAM; Sterile alpha motif
    pfam00836
    Location:416 → 524
    Stathmin; Stathmin family
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 470
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_011545309.3 → XP_011543611.1  liprin-alpha-1 isoform X4

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (6) summary
    cd09562
    Location:949 → 1019
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1066 → 1131
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1151 → 1222
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1152 → 1222
    SAM; Sterile alpha motif
    pfam00836
    Location:416 → 524
    Stathmin; Stathmin family
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain

  3. XM_011545307.4 → XP_011543609.1  liprin-alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (7) summary
    cd09562
    Location:949 → 1019
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1057 → 1122
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1142 → 1213
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1143 → 1213
    SAM; Sterile alpha motif
    pfam00836
    Location:416 → 524
    Stathmin; Stathmin family
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 470
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_011545311.4 → XP_011543613.1  liprin-alpha-1 isoform X7

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (7) summary
    cd09562
    Location:949 → 1019
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1037 → 1102
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1122 → 1193
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1123 → 1193
    SAM; Sterile alpha motif
    pfam00836
    Location:416 → 524
    Stathmin; Stathmin family
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 470
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_011545312.3 → XP_011543614.1  liprin-alpha-1 isoform X8

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (7) summary
    cd09562
    Location:949 → 1019
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1036 → 1101
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1121 → 1192
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1122 → 1192
    SAM; Sterile alpha motif
    pfam00836
    Location:416 → 524
    Stathmin; Stathmin family
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 470
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_011545308.4 → XP_011543610.1  liprin-alpha-1 isoform X3

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (7) summary
    cd09562
    Location:939 → 1009
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1056 → 1121
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1141 → 1212
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1142 → 1212
    SAM; Sterile alpha motif
    pfam00836
    Location:416 → 524
    Stathmin; Stathmin family
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 470
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. XM_017018448.2 → XP_016873937.1  liprin-alpha-1 isoform X10

    UniProtKB/TrEMBL
    A0A2R8Y7R9

  8. XM_011545316.3 → XP_011543618.1  liprin-alpha-1 isoform X16

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (5) summary
    cd09562
    Location:910 → 980
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:997 → 1062
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1082 → 1153
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1083 → 1153
    SAM; Sterile alpha motif
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain

  9. XM_011545314.4 → XP_011543616.1  liprin-alpha-1 isoform X11

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (6) summary
    cd09562
    Location:900 → 970
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1017 → 1082
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1102 → 1173
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1103 → 1173
    SAM; Sterile alpha motif
    pfam00836
    Location:416 → 524
    Stathmin; Stathmin family
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain

  10. XM_047427770.1 → XP_047283726.1  liprin-alpha-1 isoform X18

  11. XM_047427772.1 → XP_047283728.1  liprin-alpha-1 isoform X21

  12. XM_011545317.3 → XP_011543619.1  liprin-alpha-1 isoform X19

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (5) summary
    cd09562
    Location:900 → 970
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:987 → 1052
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1072 → 1143
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1073 → 1143
    SAM; Sterile alpha motif
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain

  13. XM_047427773.1 → XP_047283729.1  liprin-alpha-1 isoform X22

  14. XM_011545310.4 → XP_011543612.1  liprin-alpha-1 isoform X6

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (6) summary
    cd09562
    Location:924 → 994
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1041 → 1106
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1126 → 1197
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1127 → 1197
    SAM; Sterile alpha motif
    pfam12795
    Location:321 → 517
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 445
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  15. XM_047427766.1 → XP_047283722.1  liprin-alpha-1 isoform X12

  16. XM_047427765.1 → XP_047283721.1  liprin-alpha-1 isoform X9

  17. XM_047427767.1 → XP_047283723.1  liprin-alpha-1 isoform X14

  18. XM_047427768.1 → XP_047283724.1  liprin-alpha-1 isoform X15

  19. XM_011545315.3 → XP_011543617.1  liprin-alpha-1 isoform X13

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Related
    ENSP00000496327.1, ENST00000644155.1
    Conserved Domains (6) summary
    cd09562
    Location:885 → 955
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1002 → 1067
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1087 → 1158
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1088 → 1158
    SAM; Sterile alpha motif
    pfam12795
    Location:321 → 517
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 445
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  20. XM_011545319.2 → XP_011543621.1  liprin-alpha-1 isoform X27

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (6) summary
    cd09562
    Location:885 → 955
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:993 → 1058
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1078 → 1149
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1079 → 1149
    SAM; Sterile alpha motif
    pfam12795
    Location:321 → 517
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 445
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  21. XM_017018449.2 → XP_016873938.1  liprin-alpha-1 isoform X23

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (5) summary
    cd09562
    Location:885 → 955
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:972 → 1037
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1057 → 1128
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 441
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:270 → 517
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  22. XM_047427769.1 → XP_047283725.1  liprin-alpha-1 isoform X17

  23. XM_047427771.1 → XP_047283727.1  liprin-alpha-1 isoform X20

  24. XM_047427774.1 → XP_047283730.1  liprin-alpha-1 isoform X24

  25. XM_047427775.1 → XP_047283731.1  liprin-alpha-1 isoform X25

  26. XM_047427763.1 → XP_047283719.1  liprin-alpha-1 isoform X5

  27. XM_047427764.1 → XP_047283720.1  liprin-alpha-1 isoform X6

  28. XM_011545306.4 → XP_011543608.1  liprin-alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_011543608.1

    UniProtKB/TrEMBL
    A0A2R8Y7R9
    Conserved Domains (7) summary
    cd09562
    Location:949 → 1019
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1066 → 1131
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1151 → 1222
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1152 → 1222
    SAM; Sterile alpha motif
    pfam00836
    Location:416 → 524
    Stathmin; Stathmin family
    pfam12795
    Location:321 → 542
    MscS_porin; Mechanosensitive ion channel porin domain
    cl12013
    Location:324 → 470
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  29. XM_047427776.1 → XP_047283732.1  liprin-alpha-1 isoform X26

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160005.1 Reference GRCh38.p14 PATCHES

    Range
    26511..145684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332477.1 → XP_054188452.1  liprin-alpha-1 isoform X1

  2. XM_054332481.1 → XP_054188456.1  liprin-alpha-1 isoform X4

  3. XM_054332479.1 → XP_054188454.1  liprin-alpha-1 isoform X2

  4. XM_054332485.1 → XP_054188460.1  liprin-alpha-1 isoform X7

  5. XM_054332486.1 → XP_054188461.1  liprin-alpha-1 isoform X8

  6. XM_054332480.1 → XP_054188455.1  liprin-alpha-1 isoform X3

  7. XM_054332488.1 → XP_054188463.1  liprin-alpha-1 isoform X10

  8. XM_054332494.1 → XP_054188469.1  liprin-alpha-1 isoform X16

  9. XM_054332489.1 → XP_054188464.1  liprin-alpha-1 isoform X11

  10. XM_054332496.1 → XP_054188471.1  liprin-alpha-1 isoform X18

  11. XM_054332499.1 → XP_054188474.1  liprin-alpha-1 isoform X21

  12. XM_054332497.1 → XP_054188472.1  liprin-alpha-1 isoform X19

  13. XM_054332500.1 → XP_054188475.1  liprin-alpha-1 isoform X22

  14. XM_054332483.1 → XP_054188458.1  liprin-alpha-1 isoform X6

  15. XM_054332490.1 → XP_054188465.1  liprin-alpha-1 isoform X12

  16. XM_054332487.1 → XP_054188462.1  liprin-alpha-1 isoform X9

  17. XM_054332492.1 → XP_054188467.1  liprin-alpha-1 isoform X14

  18. XM_054332493.1 → XP_054188468.1  liprin-alpha-1 isoform X15

  19. XM_054332491.1 → XP_054188466.1  liprin-alpha-1 isoform X13

  20. XM_054332505.1 → XP_054188480.1  liprin-alpha-1 isoform X27

  21. XM_054332501.1 → XP_054188476.1  liprin-alpha-1 isoform X23

  22. XM_054332495.1 → XP_054188470.1  liprin-alpha-1 isoform X17

  23. XM_054332498.1 → XP_054188473.1  liprin-alpha-1 isoform X20

  24. XM_054332502.1 → XP_054188477.1  liprin-alpha-1 isoform X24

  25. XM_054332503.1 → XP_054188478.1  liprin-alpha-1 isoform X25

  26. XM_054332482.1 → XP_054188457.1  liprin-alpha-1 isoform X5

  27. XM_054332484.1 → XP_054188459.1  liprin-alpha-1 isoform X6

  28. XM_054332478.1 → XP_054188453.1  liprin-alpha-1 isoform X1

  29. XM_054332504.1 → XP_054188479.1  liprin-alpha-1 isoform X26

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    70285642..70404818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370272.1 → XP_054226247.1  liprin-alpha-1 isoform X1

  2. XM_054370276.1 → XP_054226251.1  liprin-alpha-1 isoform X4

  3. XM_054370274.1 → XP_054226249.1  liprin-alpha-1 isoform X2

  4. XM_054370280.1 → XP_054226255.1  liprin-alpha-1 isoform X7

  5. XM_054370281.1 → XP_054226256.1  liprin-alpha-1 isoform X8

  6. XM_054370275.1 → XP_054226250.1  liprin-alpha-1 isoform X3

  7. XM_054370283.1 → XP_054226258.1  liprin-alpha-1 isoform X10

  8. XM_054370289.1 → XP_054226264.1  liprin-alpha-1 isoform X16

  9. XM_054370284.1 → XP_054226259.1  liprin-alpha-1 isoform X11

  10. XM_054370291.1 → XP_054226266.1  liprin-alpha-1 isoform X18

  11. XM_054370294.1 → XP_054226269.1  liprin-alpha-1 isoform X21

  12. XM_054370292.1 → XP_054226267.1  liprin-alpha-1 isoform X19

  13. XM_054370295.1 → XP_054226270.1  liprin-alpha-1 isoform X22

  14. XM_054370278.1 → XP_054226253.1  liprin-alpha-1 isoform X6

  15. XM_054370285.1 → XP_054226260.1  liprin-alpha-1 isoform X12

  16. XM_054370282.1 → XP_054226257.1  liprin-alpha-1 isoform X9

  17. XM_054370287.1 → XP_054226262.1  liprin-alpha-1 isoform X14

  18. XM_054370288.1 → XP_054226263.1  liprin-alpha-1 isoform X15

  19. XM_054370286.1 → XP_054226261.1  liprin-alpha-1 isoform X13

  20. XM_054370300.1 → XP_054226275.1  liprin-alpha-1 isoform X27

  21. XM_054370296.1 → XP_054226271.1  liprin-alpha-1 isoform X23

  22. XM_054370290.1 → XP_054226265.1  liprin-alpha-1 isoform X17

  23. XM_054370293.1 → XP_054226268.1  liprin-alpha-1 isoform X20

  24. XM_054370297.1 → XP_054226272.1  liprin-alpha-1 isoform X24

  25. XM_054370298.1 → XP_054226273.1  liprin-alpha-1 isoform X25

  26. XM_054370277.1 → XP_054226252.1  liprin-alpha-1 isoform X5

  27. XM_054370279.1 → XP_054226254.1  liprin-alpha-1 isoform X6

  28. XM_054370273.1 → XP_054226248.1  liprin-alpha-1 isoform X1

  29. XM_054370299.1 → XP_054226274.1  liprin-alpha-1 isoform X26

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13136.1 GenPept UniProtKB/Swiss-Prot:Q13136

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