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MIC10 Mic10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850300, updated on 2-Nov-2024

Summary

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Official Symbol
MIC10
Official Full Name
Mic10p
Primary source
SGD:S000007547
Locus tag
YCL057C-A
See related
AllianceGenome:SGD:S000007547; FungiDB:YCL057C-A; VEuPathDB:YCL057C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MCS10; MIO10; MOS1
Summary
Involved in cristae formation. Located in mitochondrial crista junction. Part of MICOS complex. Orthologous to human MICOS10 (mitochondrial contact site and cristae organizing system subunit 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MIC10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (24032..24325, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene ribosome biosynthesis protein KRR1 Neighboring gene Fyv5p Neighboring gene Adf1p Neighboring gene metalloendopeptidase Neighboring gene Pex34p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mic10 oligomerizes to bend mitochondrial inner membranes at cristae junctions. Barbot M, et al. Cell Metab, 2015 May 5. PMID 25955211
  2. Two-dimensional benzyldimethyl-n-hexadecylammonium chloride/SDS-PAGE for membrane proteomics. Zahedi RP, et al. Proteomics, 2005 Sep. PMID 16075424
  3. Central role of Mic10 in the mitochondrial contact site and cristae organizing system. Bohnert M, et al. Cell Metab, 2015 May 5. PMID 25955210
  4. A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria. Callegari S, et al. J Mol Biol, 2019 Jul 12. PMID 31103774
  5. Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin. Rampelt H, et al. J Mol Biol, 2018 Jun 22. PMID 29733859

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that Mic10 assembly is controlled by at least two distinct pathways, Mic26-Mic27 antagonism and cardiolipin binding. Simultaneous deficiency of destabilizing Mic26 and stabilizing cardiolipin leads to an intermediate effect on Mic10 oligomers.
    Title: Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin.
  2. Mic10 interacts with the dimeric form of mitochondrial F1Fo-ATP synthase.
    Title: Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F(1)F(o)-ATP Synthase.
  3. Data indicate that Fcj1 and Mos1 are required for maintaining mitochondrial DNA (mtDNA) nucleoid size.
    Title: Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology.
  4. Proteomic analyses reveal MINOS1/Mio10 as a novel constituent of Mitofilin/Fcj1 complexes in human and yeast mitochondria.
    Title: MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of MICOS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MICOS complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial crista junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mic10p
NP_065435.1
  • Conserved component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic12p and Mic27p whose assembly and stability requires cardiolipin; homo-oligomers cause membrane bending; ortholog of human MINOS1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    24032..24325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184448.1 → NP_065435.1  TPA: Mic10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_065435.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQV9, Q96VH5
    UniProtKB/TrEMBL
    A6ZTD7, B3LU27, C7GT12, C8Z433, G2W9X0, N1PAQ4
    Conserved Domains (1) summary
    pfam04418
    Location:4 → 87
    DUF543; Domain of unknown function (DUF543)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96VH5.1

Gene LinkOut

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