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PBN1 Pbn1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850305, updated on 28-Oct-2024

Summary

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Official Symbol
PBN1
Official Full Name
Pbn1p
Primary source
SGD:S000000557
Locus tag
YCL052C
See related
AllianceGenome:SGD:S000000557; FungiDB:YCL052C; VEuPathDB:YCL052C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to mannosyltransferase activity. Involved in ERAD pathway; GPI anchor biosynthetic process; and protein processing. Located in endoplasmic reticulum. Part of glycosylphosphatidylinositol-mannosyltransferase I complex. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PBN1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (34143..35393, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Rdt1p Neighboring gene 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase Neighboring gene Lre1p Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pbn1p: an essential endoplasmic reticulum membrane protein required for protein processing in the endoplasmic reticulum of budding yeast. Subramanian S, et al. Proc Natl Acad Sci U S A, 2006 Jan 24. PMID 16418276, Free PMC Article
  2. Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Lai MH, et al. Yeast, 1997 Mar 15. PMID 9090049
  3. The PBN1 gene of Saccharomyces cerevisiae: an essential gene that is required for the post-translational processing of the protease B precursor. Naik RR, et al. Genetics, 1998 Jul. PMID 9649520, Free PMC Article
  4. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Ashida H, et al. Mol Biol Cell, 2005 Mar. PMID 15635094, Free PMC Article
  5. Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. Murley A, et al. J Cell Biol, 2015 May 25. PMID 25987606, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pbn1p is required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum (ER) and is therefore an essential chaperone-like protein in the ER of yeast
    Title: Pbn1p: an essential endoplasmic reticulum membrane protein required for protein processing in the endoplasmic reticulum of budding yeast.
  2. mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I
    Title: Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of glycosylphosphatidylinositol-mannosyltransferase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-mannosyltransferase I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pbn1p
NP_009878.1
  • Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    34143..35393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178697.1 → NP_009878.1  TPA: Pbn1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009878.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQW4, P25580
    UniProtKB/TrEMBL
    B3LU32, C7GT07, C8Z437, G2W9X5
    Conserved Domains (1) summary
    smart00780
    Location:224 → 406
    PIG-X; PIG-X / PBN1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25580.1

Gene LinkOut

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