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APA1 bifunctional AP-4-A phosphorylase/ADP sulfurylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850307, updated on 28-Oct-2024

Summary

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Official Symbol
APA1
Official Full Name
bifunctional AP-4-A phosphorylase/ADP sulfurylase
Primary source
SGD:S000000555
Locus tag
YCL050C
See related
AllianceGenome:SGD:S000000555; FungiDB:YCL050C; VEuPathDB:YCL050C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DTP1
Summary
Enables bis(5'-nucleosyl)-tetraphosphatase activity and sulfate adenylyltransferase (ADP) activity. Involved in nucleoside catabolic process and nucleotide biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See APA1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (37836..38801, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Pbn1p Neighboring gene Lre1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physical mapping of the Saccharomyces cerevisiae Ap4A phosphorylase I-encoding gene by the Achilles' cleavage method. Garrison PN, et al. Gene, 1992 Feb 1. PMID 1312500
  2. Synthesis and use of a chromogenic substrate analog for Ap4A catabolic enzymes. Garrison PN, et al. Anal Biochem, 1993 May 1. PMID 7685562
  3. Phosphorolytic cleavage of diadenosine 5',5'''-P1,P4-tetraphosphate. Properties of homogeneous diadenosine 5',5'''-P1,P4-tetraphosphate alpha, beta-phosphorylase from Saccharomyces cerevisiae. Guranowski A, et al. J Biol Chem, 1985 Mar 25. PMID 2982863
  4. A paradoxical increase of a metabolite upon increased expression of its catabolic enzyme: the case of diadenosine tetraphosphate (Ap4A) and Ap4A phosphorylase I in Saccharomyces cerevisiae. Avila DM, et al. J Bacteriol, 1991 Dec. PMID 1660456, Free PMC Article
  5. Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase. Plateau P, et al. J Bacteriol, 1989 Dec. PMID 2556364, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP:ADP adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables bis(5'-nucleosyl)-tetraphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bis(5'-nucleosyl)-tetraphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables bis(5'-nucleosyl)-tetraphosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables bis(5'-nucleosyl)-tetraphosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate adenylyltransferase (ADP) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate adenylyltransferase (ADP) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfate adenylyltransferase (ADP) activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate adenylyltransferase (ADP) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleoside catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional AP-4-A phosphorylase/ADP sulfurylase
NP_009880.2
  • AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    37836..38801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178695.1 → NP_009880.2  TPA: bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009880.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQW6, P16550
    UniProtKB/TrEMBL
    A6ZTE4, B3LU34, B5VER2, C7GT05, C8Z439, G2W9X7, N1PAN8
    Conserved Domains (1) summary
    COG4360
    Location:2 → 310
    APA2; ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16550.4

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