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SRO9 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850320, updated on 22-Aug-2024

Summary

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Official Symbol
SRO9
Primary source
FungiDB:YCL037C
Locus tag
YCL037C
See related
SGD:S000000542; AllianceGenome:SGD:S000000542; VEuPathDB:YCL037C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Involved in regulation of translation. Located in cytoplasmic stress granule. Part of polysome. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator) and LARP1B (La ribonucleoprotein 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (57374..58678, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene glucose-induced degradation complex subunit GID7 Neighboring gene Atg22p Neighboring gene Gfd2p Neighboring gene dithiol glutaredoxin GRX1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs. Jennings MD, et al. Nucleic Acids Res, 2023 Jun 23. PMID 37070186, Free PMC Article
  2. Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae. Pandita M, et al. J Biochem Mol Toxicol, 2021 Jul. PMID 33797855
  3. Multiple mechanisms of suppression circumvent transcription defects in an RNA polymerase mutant. Tan Q, et al. Mol Cell Biol, 2000 Nov. PMID 11027282, Free PMC Article
  4. Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Sobel SG, et al. Mol Biol Cell, 1999 Nov. PMID 10564276, Free PMC Article
  5. Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p. Tsukada M, et al. J Cell Sci, 1996 Oct. PMID 8923208

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs.
    Title: Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs.
  2. Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae.
    Title: Genetic interaction between glyoxylate pathway regulator UCC1 and La-motif-encoding SRO9 regulates stress response and growth rate improvement in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sro9p
NP_009893.2
  • Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; role in preventing L-A mycovirus pathogenesis; SRO9 has a paralog, SLF1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    57374..58678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178682.1 → NP_009893.2  TPA: Sro9p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009893.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQX8, P25567
    UniProtKB/TrEMBL
    A6ZTF3, B3LU45, C7GSZ4, C8Z452, G2W9Y8, N1P984
    Conserved Domains (1) summary
    COG5193
    Location:1 → 434
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25567.2

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