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LSB5 Lsb5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850323, updated on 18-Sep-2024

Summary

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Official Symbol
LSB5
Official Full Name
Lsb5p
Primary source
SGD:S000000539
Locus tag
YCL034W
See related
AllianceGenome:SGD:S000000539; FungiDB:YCL034W; VEuPathDB:YCL034W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in actin cortical patch localization; actin filament organization; and endocytosis. Located in actin cortical patch. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LSB5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (61658..62722)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Gfd2p Neighboring gene dithiol glutaredoxin GRX1 Neighboring gene peptide-methionine (R)-S-oxide reductase Neighboring gene Ste50p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae. Dewar H, et al. Mol Biol Cell, 2002 Oct. PMID 12388763, Free PMC Article
  2. Interactions between Sla1p, Lsb5p and Arf3p in yeast endocytosis. Costa R, et al. Biochem Soc Trans, 2005 Dec. PMID 16246096
  3. Lsb5p interacts with actin regulators Sla1p and Las17p, ubiquitin and Arf3p to couple actin dynamics to membrane trafficking processes. Costa R, et al. Biochem J, 2005 May 1. PMID 15651983, Free PMC Article
  4. Multiple pathways regulate endocytic coat disassembly in Saccharomyces cerevisiae for optimal downstream trafficking. Toret CP, et al. Traffic, 2008 May. PMID 18298676
  5. The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex. Madania A, et al. Mol Biol Cell, 1999 Oct. PMID 10512884, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cortical patch localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament organization IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
Lsb5p
NP_009896.2
  • Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    61658..62722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178679.1 → NP_009896.2  TPA: Lsb5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009896.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQY1, P25369, P87004, Q8NIM9
    UniProtKB/TrEMBL
    A6ZTF6, B3LU48, B5VES5, C7GSZ1, C8Z455, G2W9Z1, N1P986
    Conserved Domains (2) summary
    cd16980
    Location:12 → 158
    VHS_Lsb5; VHS (Vps27/Hrs/STAM) domain of LAS seventeen-binding protein 5
    cd14232
    Location:219 → 295
    GAT_LSB5; canonical GAT domain found in yeast LAS seventeen-binding protein 5 (Lsb5p) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25369.3

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