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FUS1 Fus1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850330, updated on 18-Sep-2024

Summary

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Official Symbol
FUS1
Official Full Name
Fus1p
Primary source
SGD:S000000532
Locus tag
YCL027W
See related
AllianceGenome:SGD:S000000532; FungiDB:YCL027W; VEuPathDB:YCL027W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cytogamy; maintenance of protein location in cell cortex; and regulation of termination of mating projection growth. Located in mating projection tip. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FUS1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (71803..73341)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Bik1p Neighboring gene prion domain-containing protein RNQ1 Neighboring gene putative nitroreductase Neighboring gene type II nitroreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quantitation of alpha-factor internalization and response during the Saccharomyces cerevisiae cell cycle. Zanolari B, et al. Mol Cell Biol, 1991 Oct. PMID 1656226, Free PMC Article
  2. Yeast pheromone signaling pathway as a bioassay to assess the effect of chemicals on mammalian peptide hormones. Fujita K, et al. Ecotoxicol Environ Saf, 2003 Nov. PMID 14575675
  3. FUS1 regulates the opening and expansion of fusion pores between mating yeast. Nolan S, et al. Mol Biol Cell, 2006 May. PMID 16495338, Free PMC Article
  4. The yeast cell fusion protein FUS1 is O-glycosylated and spans the plasma membrane. Trueheart J, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2690078, Free PMC Article
  5. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. McCaffrey G, et al. Mol Cell Biol, 1987 Aug. PMID 3313002, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results identify a sorting signal in the yeast cell fusion protein Fus1p that is required for its transport from the trans-Golgi compartment to the plasma membrane.
    Title: The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast.
  2. dramatic alterations in SH3 domain of Fus1 specificity can be simply explained as a modulation of the binding strengths of these two surfaces.
    Title: Recognition of non-canonical peptides by the yeast Fus1p SH3 domain: elucidation of a common mechanism for diverse SH3 domain specificities.
  3. Fus1p localization to the tip of the mating projection is determined by its cytosolic domain, which binds to peripheral proteins involved in mating tip polarization.
    Title: Plasma membrane polarization during mating in yeast cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytogamy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of protein location in cell cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in mating projection tip HDA PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Fus1p
NP_009903.2
  • Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    71803..73341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178672.1 → NP_009903.2  TPA: Fus1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009903.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQY8, P11710
    UniProtKB/TrEMBL
    A6ZTG3, B3LU55, B5VET1, C8Z461, G2W9Z8, N1P664
    Conserved Domains (1) summary
    cd11854
    Location:440 → 509
    SH3_Fus1p; Src homology 3 domain of yeast cell fusion protein Fus1p
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11710.3

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