U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AGP1 amino acid transporter AGP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850333, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
AGP1
Official Full Name
amino acid transporter AGP1
Primary source
SGD:S000000530
Locus tag
YCL025C
See related
AllianceGenome:SGD:S000000530; FungiDB:YCL025C; VEuPathDB:YCL025C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
WAP1; YCC5
Summary
Enables L-proline transmembrane transporter activity. Involved in serine import across plasma membrane. Located in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AGP1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (76018..77919, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative nitroreductase Neighboring gene type II nitroreductase Neighboring gene serine/threonine protein kinase Neighboring gene tRNA-Glu

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine. Schreve JL, et al. J Bacteriol, 1998 May. PMID 9573211, Free PMC Article
  2. [Effects of transporter Agp1p ubiquitination on nitrogen utilization in Saccharomyces cerevisiae]. Li Y, et al. Wei Sheng Wu Xue Bao, 2015 May 4. PMID 26259481
  3. Mapping genetic variants underlying differences in the central nitrogen metabolism in fermenter yeasts. Jara M, et al. PLoS One, 2014. PMID 24466135, Free PMC Article
  4. L-Phenylalanine Transport in Saccharomyces cerevisiae: Participation of GAP1, BAP2, and AGP1. Sáenz DA, et al. J Amino Acids, 2014. PMID 24701347, Free PMC Article
  5. Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast. Andréasson C, et al. Yeast, 2004 Feb. PMID 14968425

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of the broad-specificity amino acid permease Agp1 mediated by the ubiquitin ligase Rsp5 and the arrestin-like protein Bul1 in yeast.
    Title: Downregulation of the broad-specificity amino acid permease Agp1 mediated by the ubiquitin ligase Rsp5 and the arrestin-like protein Bul1 in yeast.
  2. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
    Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
  3. Ubiquitination sites of Agp1 significantly affect the nitrogen utilization.
    Title: [Effects of transporter Agp1p ubiquitination on nitrogen utilization in Saccharomyces cerevisiae].
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-proline transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylalanine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proline transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in serine import across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in serine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
amino acid transporter AGP1
NP_009905.3
  • Broad-specificity, low-affinity amino acid permease; minor serine permease with major contributions from paralog Gnp1p; involved in uptake of asparagine, glutamine, and other amino acids; expression induced by amino acids and regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    76018..77919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178671.1 → NP_009905.3  TPA: amino acid transporter AGP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009905.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQZ1, P25376
    UniProtKB/TrEMBL
    B3LU57, C7GSY2, N1P7S5
    Conserved Domains (1) summary
    TIGR00913
    Location:117 → 597
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25376.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools