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STP22 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850349, updated on 22-Aug-2024

Summary

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Official Symbol
STP22
Primary source
FungiDB:YCL008C
Locus tag
YCL008C
See related
SGD:S000000514; AllianceGenome:SGD:S000000514; VEuPathDB:YCL008C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AGS1; VPL15; VPS23
Summary
Enables ubiquitin binding activity. Involved in several processes, including ATP export; protein targeting; and reticulophagy. Located in cytoplasmic side of plasma membrane and endosome. Part of ESCRT I complex. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to several human genes including TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See STP22 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (105696..106853, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Sgf29p Neighboring gene acetolactate synthase regulatory subunit Neighboring gene H(+)-transporting V0 sector ATPase subunit e Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane transport: ubiquitylation in endosomal sorting. Dupré S, et al. Curr Biol, 2001 Nov 13. PMID 11719242
  2. A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting. Erpapazoglou Z, et al. Mol Biol Cell, 2012 Jun. PMID 22493318, Free PMC Article
  3. Ubiquitination of tombusvirus p33 replication protein plays a role in virus replication and binding to the host Vps23p ESCRT protein. Barajas D, et al. Virology, 2010 Feb 20. PMID 20004458, Free PMC Article
  4. Human TSG101 does not replace Saccharomyces cerevisiae VPS23 role in the quality control of plasma membrane proteins. Blanco S, et al. FEMS Microbiol Lett, 2003 Apr 25. PMID 12725919
  5. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Babst M, et al. Traffic, 2000 Mar. PMID 11208108

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PSDP motifs of the Vps27 ESCRT-0 subunit bind to a novel electropositive N-terminal site on the UEV domain of the ESCRT-I subunit Vps23 centred on Trp16.
    Title: Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast.
  2. found that in Saccharomyces cerevisiae, Rim8 binds to both the putative seven-transmembrane pH sensor Rim21 and the ESCRT-I subunit Vps23.
    Title: Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein.
  3. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37.
    Title: Structural and functional organization of the ESCRT-I trafficking complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP export IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization to vacuole IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reticulophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ESCRT I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-binding ESCRT-I subunit protein STP22
NP_009919.3
  • Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    105696..106853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178657.1 → NP_009919.3  TPA: ubiquitin-binding ESCRT-I subunit protein STP22 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009919.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR04, P25604, P87010, P87279, Q86ZT3, Q8NIM6
    UniProtKB/TrEMBL
    B3LU67, B5VEU5, C8Z477, G2WA12, N1P808
    Conserved Domains (2) summary
    pfam05743
    Location:31 → 156
    UEV; UEV domain
    pfam09454
    Location:316 → 375
    Vps23_core; Vps23 core domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25604.3

Gene LinkOut

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