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ADP1 putative ATP-dependent permease ADP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850369, updated on 18-Sep-2024

Summary

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Official Symbol
ADP1
Official Full Name
putative ATP-dependent permease ADP1
Primary source
SGD:S000000604
Locus tag
YCR011C
See related
AllianceGenome:SGD:S000000604; FungiDB:YCR011C; VEuPathDB:YCR011C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ADP1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (133724..136873, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene amphiphysin-like protein RVS161 Neighboring gene Ady2p Neighboring gene phosphoglycerate kinase Neighboring gene DNA-directed DNA polymerase IV

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The product of the YCR105 gene located on the chromosome III from Saccharomyces cerevisiae presents homologies to ATP-dependent permeases. Purnelle B, et al. Yeast, 1991 Nov. PMID 1789009
  2. Extracellular glutathione fermentation using engineered Saccharomyces cerevisiae expressing a novel glutathione exporter. Kiriyama K, et al. Appl Microbiol Biotechnol, 2012 Nov. PMID 22526809
  3. Complete inventory of the yeast ABC proteins. Decottignies A, et al. Nat Genet, 1997 Feb. PMID 9020838
  4. Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor. Tang HM, et al. Sci Rep, 2015 Jan 20. PMID 25600293, Free PMC Article
  5. Control of Plasma Membrane Permeability by ABC Transporters. Khakhina S, et al. Eukaryot Cell, 2015 May. PMID 25724885, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adp1 was identified as a novel glutathione export ABC protein (Gxa1).
    Title: Extracellular glutathione fermentation using engineered Saccharomyces cerevisiae expressing a novel glutathione exporter.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative ATP-dependent permease ADP1
NP_009937.2
  • Putative ATP-dependent permease of the ABC transporter family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    133724..136873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178724.1 → NP_009937.2  TPA: putative ATP-dependent permease ADP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009937.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR20, P25371
    UniProtKB/TrEMBL
    A6ZTJ2, C7GQM3, C8Z498, N1PAQ0
    Conserved Domains (2) summary
    TIGR00955
    Location:402 → 1042
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    cl21504
    Location:70 → 90
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25371.2

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