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HTL1 Htl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850384, updated on 2-Nov-2024

Summary

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Official Symbol
HTL1
Official Full Name
Htl1p
Primary source
SGD:S000006439
Locus tag
YCR020W-B
See related
AllianceGenome:SGD:S000006439; FungiDB:YCR020W-B; VEuPathDB:YCR020W-B
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to contribute to chromatin binding activity. Involved in nucleosome disassembly and transcription elongation by RNA polymerase II. Part of RSC-type complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HTL1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (155320..155556)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Pet18p Neighboring gene Mak31p Neighboring gene Hsp30p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The HTL1 gene (YCR020W-b) of Saccharomyces cerevisiae is necessary for growth at 37 degrees C, and for the conservation of chromosome stability and fertility. Lanzuolo C, et al. Yeast, 2001 Oct. PMID 11571756
  2. A study of biochemical and functional interactions of Htl1p, a putative component of the Saccharomyces cerevisiae, Rsc chromatin-remodeling complex. Florio C, et al. Gene, 2007 Jun 15. PMID 17400406
  3. Dissecting the pet18 mutation in Saccharomyces cerevisiae: HTL1 encodes a 7-kDa polypeptide that interacts with components of the RSC complex. Lu YM, et al. Mol Genet Genomics, 2003 Jun. PMID 12684875
  4. The defects in cell wall integrity and G2-M transition of the ∆htl1 mutant are interconnected. Wang SL, et al. Yeast, 2012 Jan. PMID 22113782
  5. HTL1 encodes a novel factor that interacts with the RSC chromatin remodeling complex in Saccharomyces cerevisiae. Romeo MJ, et al. Mol Cell Biol, 2002 Dec. PMID 12417720, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The defects in cell wall integrity and the G(2)-M transition of the htl1 mutant are interconnected.
    Title: The defects in cell wall integrity and G2-M transition of the ∆htl1 mutant are interconnected.
  2. Htl1p binding to the RSC complex is direct and physiologically relevant
    Title: A study of biochemical and functional interactions of Htl1p, a putative component of the Saccharomyces cerevisiae, Rsc chromatin-remodeling complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to chromatin binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleosome disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Htl1p
NP_009949.1
  • Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    155320..155556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184313.1 → NP_009949.1  TPA: Htl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009949.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR30, Q9URQ5
    UniProtKB/TrEMBL
    A6ZTK2, B3LU92, C7GW75, C8Z4B0, G2WA38, N1P9A3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9URQ5.1

Gene LinkOut

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