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SYP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850396, updated on 22-Aug-2024

Summary

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Official Symbol
SYP1
Primary source
FungiDB:YCR030C
Locus tag
YCR030C
See related
SGD:S000000626; AllianceGenome:SGD:S000000626; VEuPathDB:YCR030C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YCR029C-A
Summary
Enables enzyme inhibitor activity. Involved in actin cortical patch assembly; negative regulation of catalytic activity; and septin cytoskeleton organization. Located in several cellular components, including cellular bud neck septin ring; endocytic patch; and mating projection base. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FCHO1 (FCH and mu domain containing endocytic adaptor 1); FCHO2 (FCH and mu domain containing endocytic adaptor 2); and SGIP1 (SH3GL interacting endocytic adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (173826..176438, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Fen2p Neighboring gene Rim1p Neighboring gene ncRNA Neighboring gene ribosomal 40S subunit protein S14A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cell-signaling network temporally resolves specific versus promiscuous phosphorylation. Kanshin E, et al. Cell Rep, 2015 Feb 24. PMID 25704821
  2. Neck compartmentalization as the molecular basis for the different endocytic behaviour of Chs3 during budding or hyperpolarized growth in yeast cells. Sacristan C, et al. Mol Microbiol, 2012 Mar. PMID 22295943
  3. The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation. Boettner DR, et al. Curr Biol, 2009 Dec 15. PMID 19962315, Free PMC Article
  4. Early-arriving Syp1p and Ede1p function in endocytic site placement and formation in budding yeast. Stimpson HE, et al. Mol Biol Cell, 2009 Nov. PMID 19776351, Free PMC Article
  5. Membrane-sculpting BAR domains generate stable lipid microdomains. Zhao H, et al. Cell Rep, 2013 Sep 26. PMID 24055060, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syp1 can promote internalization of Ptr2 through a recently identified clathrin-independent endocytic pathway that requires the Rho1 GTPase. These findings elucidate the mechanism of Syp1 cargo recognition and its role in trafficking.
    Title: Syp1 regulates the clathrin-mediated and clathrin-independent endocytosis of multiple cargo proteins through a novel sorting motif.
  2. These data identify Syp1 as a novel negative regulator of WASp-Arp2/3 complex that helps choreograph the precise timing of actin assembly during endocytosis.
    Title: The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation.
  3. Results suggest that Ede1p and Syp1p are conserved, early-arriving endocytic proteins with roles in the formation and placement of endocytic sites, respectively.
    Title: Early-arriving Syp1p and Ede1p function in endocytic site placement and formation in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cortical patch assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in septin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in septin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin cytoskeleton organization IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck septin ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic patch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mating projection base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
Syp1p
NP_009959.2
  • Inhibitor of Las17p-mediated Arp2/3 complex activation; F-BAR protein that directly inhibits Las17p stimulation of Arp2/3 complex-mediated actin assembly in vitro; involved in formation of the endocytic site; intrinsically disordered domain induces bundling of Cdc11p-capped septin filaments to promote septin collar assembly, similar to mammalian ortholog FCHo2; localizes to sites of polarized growth, the septin ring, and endocytic patches; involved in actin cytoskeletal organization

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    173826..176438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178744.1 → NP_009959.2  TPA: Syp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009959.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR40, P25622, P25623, Q96VH0
    UniProtKB/TrEMBL
    A6ZTL1, B3LUA1, C8Z4C0, N1P9A7
    Conserved Domains (4) summary
    cd07650
    Location:16 → 250
    F-BAR_Syp1p_like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of yeast Syp1 protein
    PHA03247
    Location:409 → 574
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:251 → 530
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam10291
    Location:610 → 867
    muHD; Muniscin C-terminal mu homology domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25623.3

Gene LinkOut

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