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PER1 Per1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850411, updated on 28-Oct-2024

Summary

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Official Symbol
PER1
Official Full Name
Per1p
Primary source
SGD:S000000640
Locus tag
YCR044C
See related
AllianceGenome:SGD:S000000640; FungiDB:YCR044C; VEuPathDB:YCR044C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
COS16
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Involved in GPI anchor biosynthetic process and intracellular manganese ion homeostasis. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 4. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PER1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (206877..207950, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Rrt12p Neighboring gene mitochondrial 54S ribosomal protein IMG1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency and the sex chromosomes from yeasts to humans. de Clare M, et al. BMC Biol, 2011 Feb 28. PMID 21356089, Free PMC Article
  2. PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins. Fujita M, et al. Mol Biol Cell, 2006 Dec. PMID 17021251, Free PMC Article
  3. Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling. Losev E, et al. Mol Cell Biol, 2008 May. PMID 18332110, Free PMC Article
  4. Determination and physiological roles of the glycosylphosphatidylinositol lipid remodelling pathway in yeast. Yoko-O T, et al. Mol Microbiol, 2013 Apr. PMID 23421703
  5. The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum. Sahu PK, et al. J Biol Chem, 2019 Mar 15. PMID 30659098, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular manganese ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Per1p
NP_009973.1
  • Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    206877..207950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178758.1 → NP_009973.1  TPA: Per1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009973.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR53, P25625
    UniProtKB/TrEMBL
    A6ZTM5, B3LUA9, C8Z4D4, G2WA61, N1P6B9
    Conserved Domains (1) summary
    COG5237
    Location:1 → 357
    PER1; Predicted membrane protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25625.1

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