ERS1 cystinosin-like protein ERS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ERS1
Official Full Name: cystinosin-like protein ERS1
Primary source: SGD:S000000671
Locus tag: YCR075C
See related: AllianceGenome:SGD:S000000671; FungiDB:YCR075C; VEuPathDB:YCR075C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables L-cystine transmembrane transporter activity. Involved in L-cystine transport. Located in endosome; fungal-type vacuole; and plasma membrane. Used to study several diseases, including carcinoma (multiple); colorectal cancer (multiple); congenital disorder of glycosylation type IIj; cystinosis; and hypoglycemia (multiple). Human ortholog(s) of this gene implicated in cystinosis. Orthologous to human CTNS (cystinosin, lysosomal cystine transporter). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-cystine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-cystine transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-cystine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-cystine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-cystine transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in fungal-type vacuole	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_010000.1

Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS