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FUB1 Fub1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850439, updated on 2-Nov-2024

Summary

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Official Symbol
FUB1
Official Full Name
Fub1p
Primary source
SGD:S000000672
Locus tag
YCR076C
See related
AllianceGenome:SGD:S000000672; FungiDB:YCR076C; VEuPathDB:YCR076C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables proteasome binding activity. Predicted to be involved in chromatin organization. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FUB1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (249293..250045, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene cystinosin-like protein ERS1 Neighboring gene Ego2p Neighboring gene Pat1p Neighboring gene type 2C protein phosphatase PTC6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Rawson S, et al. Nat Struct Mol Biol, 2022 Aug. PMID 35927584, Free PMC Article
  2. Barrier proteins remodel and modify chromatin to restrict silenced domains. Oki M, et al. Mol Cell Biol, 2004 Mar. PMID 14966276, Free PMC Article
  3. N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function. Yashiroda H, et al. Mol Cell Biol, 2015 Jan. PMID 25332237, Free PMC Article
  4. Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex. Hatanaka A, et al. Genes Genet Syst, 2011. PMID 22362029
  5. The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation. Buck TM, et al. Mol Cell Proteomics, 2020 Nov. PMID 32868373, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Fub1p
NP_010001.1
  • Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; specifically blocks all three proteasome active sites; exhibits boundary activity which inhibits the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    249293..250045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178785.1 → NP_010001.1  TPA: Fub1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010001.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR79, P25659
    UniProtKB/TrEMBL
    G2WA86
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25659.1

Gene LinkOut

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