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PTC6 type 2C protein phosphatase PTC6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850441, updated on 1-Aug-2024

Summary

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Gene symbol
PTC6
Gene description
type 2C protein phosphatase PTC6
Primary source
FungiDB:YCR079W
Locus tag
YCR079W
See related
SGD:S000002133; AllianceGenome:SGD:S000002133; VEuPathDB:YCR079W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AUP1; PPP2
Summary
Enables [pyruvate dehydrogenase (lipoamide)] phosphatase activity and protein serine/threonine phosphatase activity. Involved in several processes, including autophagy of mitochondrion; peptidyl-serine dephosphorylation; and positive regulation of pyruvate dehydrogenase activity. Located in mitochondrial intermembrane space and mitochondrial matrix. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PTC6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (252845..254173)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Fub1p Neighboring gene Pat1p Neighboring gene Srb8p Neighboring gene Ahc2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Candida albicans CaPTC6 is a functional homologue for Saccharomyces cerevisiae ScPTC6 and encodes a type 2C protein phosphatase. Yu L, et al. Yeast, 2010 Apr. PMID 20033882
  2. The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. Ruan H, et al. FEMS Yeast Res, 2007 Mar. PMID 17002782
  3. Type 2C protein phosphatase Ptc6 participates in activation of the Slt2-mediated cell wall integrity pathway in Saccharomyces cerevisiae. Sharmin D, et al. J Biosci Bioeng, 2015 Apr. PMID 25449759
  4. Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. Tal R, et al. J Biol Chem, 2007 Feb 23. PMID 17166847
  5. Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. Gey U, et al. J Biol Chem, 2008 Apr 11. PMID 18180296

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that Ptc6p is the primary pyruvate dehydrogenase phosphatase in S. cerevisiae; Ptc6p exhibits substrate specificity for additional phosphatases.
    Title: Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase.
  2. S. cerevisiae PTC6 participates in the negative regulation of Slt2 phosphorylation and vacuole morphogenesis under cell wall stress conditions
    Title: Type 2C protein phosphatase Ptc6 participates in activation of the Slt2-mediated cell wall integrity pathway in Saccharomyces cerevisiae.
  3. the function of Aup1 in mitophagy could be explained through its regulation of Rtg3-dependent transcription.
    Title: Aup1-mediated regulation of Rtg3 during mitophagy.
  4. Pkp2p (Ygl059wp) and Ppp2p (Ycr079wp), are engaged in the regulation of this complex by affecting the phosphorylation state of Pda1p.
    Title: Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases.
  5. encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae and confers rapamycin-resistant function.
    Title: The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type 2C protein phosphatase PTC6
NP_010003.2
  • Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    252845..254173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180034.1 → NP_010003.2  TPA: type 2C protein phosphatase PTC6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010003.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR81, P25646, Q8NIL5
    UniProtKB/TrEMBL
    A6ZTQ2, C7GUW8, G2WA88, N1PAN4
    Conserved Domains (1) summary
    pfam00481
    Location:108 → 401
    PP2C; Protein phosphatase 2C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25646.2

Gene LinkOut

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