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KIN82 putative serine/threonine protein kinase KIN82 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850453, updated on 18-Sep-2024

Summary

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Official Symbol
KIN82
Official Full Name
putative serine/threonine protein kinase KIN82
Primary source
SGD:S000000687
Locus tag
YCR091W
See related
AllianceGenome:SGD:S000000687; FungiDB:YCR091W; VEuPathDB:YCR091W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FPK2
Summary
Enables protein kinase activity. Involved in phospholipid translocation; protein phosphorylation; and response to pheromone triggering conjugation with cellular fusion. Predicted to be active in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KIN82 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (274404..276566)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Fig2p Neighboring gene uncharacterized protein Neighboring gene mismatch repair protein MSH3 Neighboring gene CCR4-NOT core subunit CDC39

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A putative serine/threonine protein kinase gene on chromosome III of Saccharomyces cerevisiae. Wilson C, et al. Yeast, 1992 Jan. PMID 1580103
  2. Mutations in N-terminal flanking region of blue light-sensing light-oxygen and voltage 2 (LOV2) domain disrupt its repressive activity on kinase domain in the Chlamydomonas phototropin. Aihara Y, et al. J Biol Chem, 2012 Mar 23. PMID 22291022, Free PMC Article
  3. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Segal E, et al. Nat Genet, 2003 Jun. PMID 12740579
  4. Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Nakano K, et al. Mol Biol Cell, 2008 Apr. PMID 18199685, Free PMC Article
  5. An optogenetic system to control membrane phospholipid asymmetry through flippase activation in budding yeast. Suzuki T, et al. Sci Rep, 2020 Jul 27. PMID 32719316, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fpk1 and Fpk2 were involved in two downstream events; that is, ISP-1 uptake due to aminophospholipid flippase and sphingoid long-chain base degradation due to LCB4 expression.
    Title: Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance to LCB elevation or depletion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone triggering conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative serine/threonine protein kinase KIN82
NP_010015.3
  • Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog, FPK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    274404..276566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178797.2 → NP_010015.3  TPA: putative serine/threonine protein kinase KIN82 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010015.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR91, P25341
    UniProtKB/TrEMBL
    A6ZTR2, B3LUE3
    Conserved Domains (1) summary
    cd05574
    Location:322 → 623
    STKc_phototropin_like; Catalytic domain of Phototropin-like Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25341.3

Gene LinkOut

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