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HMRA2 homeodomain mating type protein a2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850458, updated on 2-Nov-2024

Summary

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Official Symbol
HMRA2
Official Full Name
homeodomain mating type protein a2
Primary source
SGD:S000000692
Locus tag
YCR096C
See related
AllianceGenome:SGD:S000000692; FungiDB:YCR096C; VEuPathDB:YCR096C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
A2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HMRA2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (293179..293538, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Oca4p Neighboring gene uncharacterized protein Neighboring gene Hmra1p Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diversity of Y region at HML locus in a Saccharomyces cerevisiae strain isolated from a Sardinian wine. Pirino G, et al. Antonie Van Leeuwenhoek, 2004 Jan. PMID 15031661
  2. Regulation of yeast mating-type interconversion: feedback control of HO gene expression by the mating-type locus. Jensen R, et al. Proc Natl Acad Sci U S A, 1983 May. PMID 6344075, Free PMC Article
  3. The Action of Homothallism Genes in Saccharomyces Diploids during Vegetative Growth and the Equivalence of hma and HMalpha Loci Functions. Klar AJ, et al. Genetics, 1977 Mar. PMID 17248737, Free PMC Article
  4. On the Mechanism of Gene Silencing in Saccharomyces cerevisiae. Steakley DL, et al. G3 (Bethesda), 2015 Jun 16. PMID 26082137, Free PMC Article
  5. The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae. Astell CR, et al. Cell, 1981 Nov. PMID 7034964

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeodomain mating type protein a2
NP_010020.1
  • Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    293179..293538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178802.1 → NP_010020.1  TPA: homeodomain mating type protein a2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010020.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR97, P0CY12, P0CY13, Q6B184
    UniProtKB/TrEMBL
    A6ZTC7, B3LUE9, B5VF26, C8Z4I3, G2WAA5, N1P852
    Conserved Domains (1) summary
    smart00389
    Location:44 → 97
    HOX; Homeodomain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CY13.1

Gene LinkOut

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