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SNZ3 pyridoxine biosynthesis protein SNZ3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850485, updated on 2-Nov-2024

Summary

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Official Symbol
SNZ3
Official Full Name
pyridoxine biosynthesis protein SNZ3
Primary source
SGD:S000001835
Locus tag
YFL059W
See related
AllianceGenome:SGD:S000001835; FungiDB:YFL059W; VEuPathDB:YFL059W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity. Involved in pyridoxine biosynthetic process and thiamine biosynthetic process. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SNZ3 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (11363..12259)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene cyanamide hydratase Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence analysis of an exceptionally conserved operon suggests enzymes for a new link between histidine and purine biosynthesis. Galperin MY, et al. Mol Microbiol, 1997 Apr. PMID 9159529
  2. Identification of novel metabolic engineering targets for S-adenosyl-L-methionine production in Saccharomyces cerevisiae via genome-scale engineering. Dong C, et al. Metab Eng, 2021 Jul. PMID 33713797
  3. A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family. Braun EL, et al. J Bacteriol, 1996 Dec. PMID 8955308, Free PMC Article
  4. Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Ito T, et al. Proc Natl Acad Sci U S A, 2000 Feb 1. PMID 10655498, Free PMC Article
  5. SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae. Paxhia MD, et al. G3 (Bethesda), 2019 Feb 7. PMID 30498136, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Snz3p is a pyridoxal 5'-phosphate synthase required for thiamine biosynthesis.
    Title: SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amine-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organic hydroxy compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyridoxal phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridoxal phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyridoxine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridoxine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in thiamine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vitamin B6 biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
pyridoxine biosynthesis protein SNZ3
NP_116596.1
  • Pyridoxal-5'-phosphate synthase; involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamine in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO3; paralog of SNZ1 and SNZ2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    11363..12259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179908.1 → NP_116596.1  TPA: pyridoxine biosynthesis protein SNZ3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116596.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTH1, P43545
    UniProtKB/TrEMBL
    B3LPG5, B5VQ90, C8ZBV7
    Conserved Domains (1) summary
    TIGR00343
    Location:6 → 298
    TIGR00343; pyridoxal 5'-phosphate synthase, synthase subunit Pdx1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43545.1

Gene LinkOut

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