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ALR2 putative Mg(2+) transporter ALR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850494, updated on 2-Nov-2024

Summary

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Official Symbol
ALR2
Official Full Name
putative Mg(2+) transporter ALR2
Primary source
SGD:S000001844
Locus tag
YFL050C
See related
AllianceGenome:SGD:S000001844; FungiDB:YFL050C; VEuPathDB:YFL050C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables inorganic cation transmembrane transporter activity. Involved in magnesium ion transport and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ALR2 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (33272..35848, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene DNA-binding domain containing protein Neighboring gene uncharacterized protein Neighboring gene Swp82p Neighboring gene Emp47p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Large Mg(2+)-dependent currents are associated with the increased expression of ALR1 in Saccharomyces cerevisiae. Liu GJ, et al. FEMS Microbiol Lett, 2002 Aug 6. PMID 12167543
  2. The function of Alr1p of Saccharomyces cerevisiae in cadmium detoxification: insights from phylogenetic studies and particle-induced X-ray emission. Kern AL, et al. Biometals, 2005 Feb. PMID 15865408
  3. Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane. Wachek M, et al. FEBS J, 2006 Sep. PMID 16903865
  4. Manipulation of intracellular magnesium levels in Saccharomyces cerevisiae with deletion of magnesium transporters. da Costa BM, et al. Appl Microbiol Biotechnol, 2007 Nov. PMID 17926032
  5. Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. MacDiarmid CW, et al. J Biol Chem, 1998 Jan 16. PMID 9430719

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables inorganic cation transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular magnesium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in magnesium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
putative Mg(2+) transporter ALR2
NP_116604.1
  • Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    33272..35848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179917.1 → NP_116604.1  TPA: putative Mg(2+) transporter ALR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116604.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTI0, P43553
    UniProtKB/TrEMBL
    G2WD91, N1P4G7
    Conserved Domains (1) summary
    cd12829
    Location:455 → 796
    Alr1p-like; Saccharomyces cerevisiae Alr1p-like subfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43553.1

Gene LinkOut

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