ACT1 actin [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ACT1
Official Full Name: actin
Primary source: SGD:S000001855
Locus tag: YFL039C
See related: AllianceGenome:SGD:S000001855; FungiDB:YFL039C; VEuPathDB:YFL039C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ABY1; END7
Summary: Enables ATP hydrolysis activity. A structural constituent of cytoskeleton. Involved in several processes, including ascospore wall assembly; mitotic actomyosin contractile ring contraction; and vacuole inheritance. Located in actin cytoskeleton. Part of Ino80 complex; NuA4 histone acetyltransferase complex; and Swr1 complex. Used to study Baraitser-Winter syndrome 1; artery disease (multiple); autosomal dominant nonsyndromic deafness 20; intestinal atresia; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; artery disease (multiple); congenital myopathy (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ACT1 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 2

Sequence:: Chromosome: VI; NC_001138.5 (53260..54696, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.
Title: Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.
Mechanical stiffness of reconstituted actin patches correlates tightly with endocytosis efficiency.
Title: Mechanical stiffness of reconstituted actin patches correlates tightly with endocytosis efficiency.
The authors show that the type-I myosins Myo3 and Myo5 promote, in a dose-dependent way, the growth and expansion of the actin network, which controls the speed of membrane and coat internalization.
Title: Type-I myosins promote actin polymerization to drive membrane bending in endocytosis.
Act1 protein affects tombusvirus recombination in yeast .
Title: Screening a yeast library of temperature-sensitive mutants reveals a role for actin in tombusvirus RNA recombination.
Using multi-color total internal reflection fluorescence microscopy, the study shows that Crn1 enhances Cof1-mediated severing by accelerating Cof1 binding to actin filament sides.
Title: Coronin Enhances Actin Filament Severing by Recruiting Cofilin to Filament Sides and Altering F-Actin Conformation.
Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2alpha phosphorylation.
Title: Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2α phosphorylation.
Heat shock-induced processing of actin assembly protein Lsb1 is involved in prion inheritance.
Title: Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.
Data suggest that a glycolytic multi-enzyme complex assembles in cytoplasm of S. cerevisiae in association with F-actin (filamentous actin) but not in association with G-actin (monomeric globular actin).
Title: A glycolytic metabolon in Saccharomyces cerevisiae is stabilized by F-actin.
Lsb1 and/or Lsb2 full-length proteins inhibit Las17-mediated actin polymerization
Title: Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis.
data suggest that the R256H actin mutation alters filament conformation resulting in filament instability and misregulation by formin
Title: Thoracic aortic aneurysm (TAAD)-causing mutation in actin affects formin regulation of polymerization.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in ascospore wall assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole inheritance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Swr1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in actin filament bundle	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck contractile ring	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intracellular non-membrane-bounded organelle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: actin

NP_116614.1

Actin, structural protein in cytoskeleton; involved in cell polarization, endocytosis, and other cytoskeletal functions; monomeric actin in the nucleus plays a role in INO80 chromatin remodeling

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

53260..54696 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179927.1 → NP_116614.1 TPA: actin [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116614.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTJ1, P60010, Q9P3X6, Q9P3X7

UniProtKB/TrEMBL

A7A200, B3LUH2, C8Z7P3, E9P9M3, G2WDA2, N1PA17

Conserved Domains (1) summary

cl17037
Location:1 → 375

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily