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MIL1 Mil1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850510, updated on 2-Nov-2024

Summary

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Official Symbol
MIL1
Official Full Name
Mil1p
Primary source
SGD:S000001860
Locus tag
YFL034W
See related
AllianceGenome:SGD:S000001860; FungiDB:YFL034W; VEuPathDB:YFL034W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables AP-1 adaptor complex binding activity. Involved in clathrin-coated vesicle cargo loading. Located in membrane. Orthologous to human TMCO4 (transmembrane and coiled-coil domains 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MIL1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (65477..68698)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Mob2p Neighboring gene ribosomal 60S subunit protein L22B Neighboring gene protein kinase RIM15 Neighboring gene transcription factor HAC1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a hypothetical membrane protein interactor of ribosomal phosphoprotein P0. Aruna K, et al. J Biosci, 2004 Mar. PMID 15286401
  2. Acquisition of a stable structure by yeast ribosomal P0 protein requires binding of P1A-P2B complex: in vitro formation of the stalk structure. Krokowski D, et al. Biochim Biophys Acta, 2005 Jun 20. PMID 15866509
  3. The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting. Whitfield ST, et al. Mol Biol Cell, 2016 Feb 1. PMID 26658609, Free PMC Article
  4. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article
  5. The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A. Samanfar B, et al. PeerJ, 2017. PMID 29158977, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mil1 is a predicted lipase that binds Apm2 but not Apm1 and contributes to its membrane recruitment.
    Title: The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables AP-1 adaptor complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in clathrin-coated vesicle cargo loading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mil1p
NP_116583.2
  • Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    65477..68698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179932.2 → NP_116583.2  TPA: Mil1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116583.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTJ7, P43564
    UniProtKB/TrEMBL
    C7GY78, N1P4W0
    Conserved Domains (1) summary
    pfam05277
    Location:541 → 875
    DUF726; Protein of unknown function (DUF726)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43564.2

Gene LinkOut

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