U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EPL1 Epl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850520, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
EPL1
Official Full Name
Epl1p
Primary source
SGD:S000001870
Locus tag
YFL024C
See related
AllianceGenome:SGD:S000001870; FungiDB:YFL024C; VEuPathDB:YFL024C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to histone acetyltransferase activity. Involved in DNA repair; positive regulation of macroautophagy; and regulation of transcription by RNA polymerase II. Part of NuA4 histone acetyltransferase complex and piccolo histone acetyltransferase complex. Orthologous to several human genes including EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See EPL1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (87847..90345, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene alpha-factor pheromone receptor STE2 Neighboring gene Bst1p Neighboring gene Bud27p Neighboring gene phenylalanine--tRNA ligase subunit alpha

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the Enhancer of Polycomb A domain and chromodomain to acetylate nucleosomes. Selleck W, et al. Mol Cell Biol, 2005 Jul. PMID 15964809, Free PMC Article
  2. Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex. Berndsen CE, et al. Biochemistry, 2007 Feb 27. PMID 17274630, Free PMC Article
  3. Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. Searle NE, et al. Genetics, 2017 Mar. PMID 28108589, Free PMC Article
  4. A simple and effective set of PCR-based molecular markers for the monitoring of the Saccharomyces cerevisiae cell population during bioethanol fermentation. Carvalho-Netto OV, et al. J Biotechnol, 2013 Dec. PMID 23994268
  5. The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism. Xu P, et al. Mol Cell, 2016 Sep 15. PMID 27594449

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epl1 domains required in vivo for interaction with specific NuA4 subunits, histone acetylation, and chromatin targeting were identified.
    Title: Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1.
  2. Data suggest that substrate specificity of Piccolo NuA4 (NuA4/Epl1/Yng2 histone acetyltransferase complex) includes acetylation of histone tetramers (H3/H4)2 and nucleosome core particles.
    Title: Site specificity analysis of Piccolo NuA4-mediated acetylation for different histone complexes.
  3. Epl1 EPcA basic region is in proximity to the N-terminal histone H2A tail, the globular region of histone H4, and also to nucleosomal DNA when Piccolo NuA4 interacts with the nucleosome.
    Title: Piccolo NuA4-catalyzed acetylation of nucleosomal histones: critical roles of an Esa1 Tudor/chromo barrel loop and an Epl1 enhancer of polycomb A (EPcA) basic region.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA4 histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of piccolo histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of piccolo histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Epl1p
NP_116629.1
  • Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    87847..90345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179942.1 → NP_116629.1  TPA: Epl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116629.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTK6, P43572
    UniProtKB/TrEMBL
    B3LUI7, C8Z7Q9, G2WDB7, N1P4X2
    Conserved Domains (1) summary
    pfam10513
    Location:56 → 197
    EPL1; Enhancer of polycomb-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43572.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools