FRS2 phenylalanine--tRNA ligase subunit alpha [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: FRS2
Official Full Name: phenylalanine--tRNA ligase subunit alpha
Primary source: SGD:S000001872
Locus tag: YFL022C
See related: AllianceGenome:SGD:S000001872; FungiDB:YFL022C; VEuPathDB:YFL022C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables aminoacyl-tRNA editing activity. Contributes to phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Located in cytoplasm. Part of phenylalanine-tRNA ligase complex. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See FRS2 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (93499..95010, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the mitochondrial protein synthesis machinery, involving MSF1, lacks the tyrosine proofreading activity characteristic of cytosolic translation with FRS2
Title: Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA editing activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity, acting on a tRNA	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to phenylalanine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables phenylalanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phenylalanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of phenylalanine-tRNA ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phenylalanine-tRNA ligase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: phenylalanine--tRNA ligase subunit alpha

NP_116631.1

EC 6.1.1.20

Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

93499..95010 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179944.2 → NP_116631.1 TPA: phenylalanine--tRNA ligase subunit alpha [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116631.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTK8, P15625

UniProtKB/TrEMBL

B3LUI8, C8Z7R1, G2WDB9, N1P357

Conserved Domains (1) summary

PTZ00326
Location:1 → 486

PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional