SMC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SMC1
Primary source: FungiDB:YFL008W
Locus tag: YFL008W
See related: SGD:S000001886; AllianceGenome:SGD:S000001886; VEuPathDB:YFL008W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CHL10
Summary: Enables double-stranded DNA binding activity and minor groove of adenine-thymine-rich DNA binding activity. Involved in double-strand break repair and mitotic sister chromatid cohesion. Located in nucleus. Part of nuclear mitotic cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2 and developmental and epileptic encephalopathy. Orthologous to human SMC1A (structural maintenance of chromosomes 1A) and SMC1B (structural maintenance of chromosomes 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (119429..123106)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP-binding and Smc1-Smc3 heterodimerization promote conformational changes within the ATPase that are transmitted to the Smc coiled-coil domains.
Title: The structure of the cohesin ATPase elucidates the mechanism of SMC-kleisin ring opening.
This study confirmed the interaction between cohesin (containing SMC1) and FACT complex (containing Spt16) in metaphase arrests using cells that expressed SMC1-6HA and SPT16-9MYC to validate that cohesin physically interacts with this histone chaperone.
Title: FACT mediates cohesin function on chromatin.
A reversible association between Smc1 and Smc3 coiled coils is regulated by lysine acetylation and is required for cohesin association with the DNA.
Title: A Reversible Association between Smc Coiled Coils Is Regulated by Lysine Acetylation and Is Required for Cohesin Association with the DNA.
We identified a large number of mutations in the CC region of both Smc1 and Smc3... we introduced them to the yeast Smc1 and Smc3 CC domains and characterized the effect of these mutant alleles on cohesin's function. We identified a missense mutation in the region of the kink domain of Smc3, which was previously identified in kidney carcinoma
Title: Identification of a region in the coiled-coil domain of Smc3 that is essential for cohesin activity.
These results also suggest that Eco1 promotes cohesion by modulating the ATPase cycle of DNA-bound cohesin in a state that is permissive for DNA tethering and refractory to Wpl1 inhibition.
Title: The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering.
Smc5/6 and cohesin complexes are interrelated and cooperating factors that control chromosome dynamics throughout interphase. [review]
Title: Functional interplay between cohesin and Smc5/6 complexes.
by retarding Topo II-driven decatenation, cohesin (Smc1, Smc3, Scc1) mediates sister chromatid cohesion by an indirect mechanism as well as one involving entrapment of sister DNAs inside its tripartite ring
Title: Cohesin's concatenation of sister DNAs maintains their intertwining.
Scc3 and Smc1 are both required for the production of the meiosis-specific subunit Rec8.
Title: Cohesin plays a dual role in gene regulation and sister-chromatid cohesion during meiosis in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA secondary structure binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in sister chromatid cohesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cohesin complex	IEA Inferred from Electronic Annotation more info
part_of mitotic cohesin complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cohesin subunit SMC1

NP_116647.1

Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

119429..123106

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179958.1 → NP_116647.1 TPA: cohesin subunit SMC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116647.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTM2, P32908

UniProtKB/TrEMBL

B3LUK2

Conserved Domains (1) summary

COG1196
Location:3 → 1225

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]