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VTC2 vacuolar transporter chaperone [ Saccharomyces cerevisiae S288C ]

Gene ID: 850544, updated on 2-Nov-2024

Summary

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Official Symbol
VTC2
Official Full Name
vacuolar transporter chaperone
Primary source
SGD:S000001890
Locus tag
YFL004W
See related
AllianceGenome:SGD:S000001890; FungiDB:YFL004W; VEuPathDB:YFL004W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PHM1
Summary
Enables calmodulin binding activity. Involved in several processes, including microautophagy; polyphosphate metabolic process; and vacuole fusion, non-autophagic. Located in endoplasmic reticulum and fungal-type vacuole membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VTC2 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (131810..134296)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Rab family GTPase SEC4 Neighboring gene ncRNA Neighboring gene MutS family protein MSH4 Neighboring gene tRNA-Asn

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. One-Step Biosynthesis of Vitamin C in Saccharomyces cerevisiae. Zhou M, et al. Front Microbiol, 2021. PMID 33717042, Free PMC Article
  2. The macro domain as fusion tag for carrier-driven crystallization. Wild R, et al. Protein Sci, 2017 Feb. PMID 27774698, Free PMC Article
  3. Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction. Pipercevic J, et al. Nat Commun, 2023 May 8. PMID 37156835, Free PMC Article
  4. Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Hothorn M, et al. Science, 2009 Apr 24. PMID 19390046
  5. Role of the Vtc proteins in V-ATPase stability and membrane trafficking. Müller O, et al. J Cell Sci, 2003 Mar 15. PMID 12584253

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microautophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyphosphate metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in polyphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vacuolar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar transporter chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar transporter chaperone complex IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar transporter chaperone complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vacuolar transporter chaperone
NP_116651.1
  • Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC2 has a paralog, VTC3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    131810..134296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179962.1 → NP_116651.1  TPA: vacuolar transporter chaperone [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116651.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTM5, P43585
    UniProtKB/TrEMBL
    A7A234, G2WDD6
    Conserved Domains (2) summary
    COG5036
    Location:1 → 555
    COG5036; SPX domain-containing protein involved in vacuolar polyphosphate accumulation [Inorganic ion transport and metabolism, Intracellular trafficking, secretion, and vesicular transport]
    COG5264
    Location:662 → 791
    VTC1; Vacuolar transporter chaperone [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43585.1

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