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PTR3 Ptr3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850587, updated on 29-Jun-2024

Summary

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Gene symbol
PTR3
Gene description
Ptr3p
Primary source
FungiDB:YFR029W
Locus tag
YFR029W
See related
SGD:S000001925; AllianceGenome:SGD:S000001925; VEuPathDB:YFR029W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RAA2; SSY3
Summary
Involved in response to amino acid. Is extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PTR3 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (210937..212973)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase CDC14 Neighboring gene tRNA-Tyr Neighboring gene sulfite reductase subunit alpha Neighboring gene condensin subunit SMC2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PTR3, a novel gene mediating amino acid-inducible regulation of peptide transport in Saccharomyces cerevisiae. Barnes D, et al. Mol Microbiol, 1998 Jul. PMID 9701822
  2. Isolation and characterization of S. cerevisiae mutants deficient in amino acid-inducible peptide transport. Island MD, et al. Curr Genet, 1991 Dec. PMID 1782673
  3. Constitutive signal transduction by mutant Ssy5p and Ptr3p components of the SPS amino acid sensor system in Saccharomyces cerevisiae. Poulsen P, et al. Eukaryot Cell, 2005 Jun. PMID 15947203, Free PMC Article
  4. Rts1-protein phosphatase 2A antagonizes Ptr3-mediated activation of the signaling protease Ssy5 by casein kinase I. Omnus DJ, et al. Mol Biol Cell, 2013 May. PMID 23447701, Free PMC Article
  5. Multiplicity and regulation of genes encoding peptide transporters in Saccharomyces cerevisiae. Hauser M, et al. Mol Membr Biol, 2001 Jan-Mar. PMID 11396605

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Saccharomyces cerevisiae Ssy5 signaling protease (SSY5) is a core component of the plasma membrane (PM)-localized Ssy1-Ptr3-Ssy5 (SPS) sensor.
    Title: Spatial and temporal regulation of the endoproteolytic activity of the SPS-sensor-controlled Ssy5 signaling protease.
  2. Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
    Title: Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
  3. Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
    Title: Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
  4. casein kinase I and PP2A phosphatase play antagonistic roles in SPS sensing by regulating Ptr3 phosphorylation
    Title: Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in response to amino acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ptr3p
NP_116685.1
  • Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    210937..212973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179994.1 → NP_116685.1  TPA: Ptr3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116685.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTQ9, P43606
    UniProtKB/TrEMBL
    A0A8H8ULB1, G2WDG7, N1P399
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43606.1

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