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RSC8 Rsc8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850598, updated on 3-Nov-2024

Summary

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Official Symbol
RSC8
Official Full Name
Rsc8p
Primary source
SGD:S000001933
Locus tag
YFR037C
See related
AllianceGenome:SGD:S000001933; FungiDB:YFR037C; VEuPathDB:YFR037C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SWH3
Summary
Enables DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; nucleosome disassembly; and transcription elongation by RNA polymerase II. Located in nucleus. Part of RSC-type complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8 and hydrocephalus. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1) and SMARCC2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RSC8 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (227513..229186, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene anaphase promoting complex subunit CDC26 Neighboring gene putative ATPase Neighboring gene Osw7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions? Pazin MJ, et al. Cell, 1997 Mar 21. PMID 9118215
  2. RSC-dependent constructive and destructive interference between opposing arrays of phased nucleosomes in yeast. Ganguli D, et al. Genome Res, 2014 Oct. PMID 25015381, Free PMC Article
  3. Temporal sequence and cell cycle cues in the assembly of host factors at the yeast 2 micron plasmid partitioning locus. Ma CH, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275556, Free PMC Article
  4. Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Da G, et al. Proc Natl Acad Sci U S A, 2006 Feb 14. PMID 16461455, Free PMC Article
  5. The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities. Aravind L, et al. Genome Biol, 2002 Jul 24. PMID 12186646, Free PMC Article

See all (135) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identification of Rsc8 and Rsc30, subunits of the Saccharomyces cerevisiae chromatin remodeling complex RSC, as novel NHEJ factors
    Title: The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rsc8p
NP_116695.3
  • Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    227513..229186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180002.3 → NP_116695.3  TPA: Rsc8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116695.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTS0, P43609, Q6B289
    UniProtKB/TrEMBL
    B3LUP8, C8Z7X3, G2WDH8, N1P3A7
    Conserved Domains (1) summary
    COG5259
    Location:26 → 557
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43609.1

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