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IRC6 Irc6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850604, updated on 2-Nov-2024

Summary

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Official Symbol
IRC6
Official Full Name
Irc6p
Primary source
SGD:S000001939
Locus tag
YFR043C
See related
AllianceGenome:SGD:S000001939; FungiDB:YFR043C; VEuPathDB:YFR043C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-macromolecule adaptor activity. Involved in vesicle-mediated transport. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See IRC6 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (239114..239827, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Erj5p Neighboring gene Keg1p Neighboring gene metallodipeptidase Neighboring gene Mrx20p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clathrin Adaptor Complex-interacting Protein Irc6 Functions through the Conserved C-Terminal Domain. Zhou H, et al. Sci Rep, 2019 Mar 14. PMID 30872642, Free PMC Article
  2. Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. Gorynia S, et al. Mol Biol Cell, 2012 Nov. PMID 22993212, Free PMC Article
  3. Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance. Bilsland E, et al. Mol Microbiol, 2004 Sep. PMID 15341652
  4. De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Zhang W, et al. Genes Dev, 2010 Mar 1. PMID 20194442, Free PMC Article
  5. Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. Alvaro D, et al. PLoS Genet, 2007 Dec. PMID 18085829, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Irc6p/p34 functions as a novel type of conserved clathrin accessory protein and founding member of a new G protein-like family.
    Title: Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Irc6p
NP_116701.3
  • Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab GTPase Ypt31p; has structural similarity to G-proteins; mouse homolog Aagab (p34) functionally complements irc6 null mutation; null mutant displays increased levels of spontaneous Rad52p foci

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    239114..239827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180008.3 → NP_116701.3  TPA: Irc6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116701.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTS6, P43615
    UniProtKB/TrEMBL
    G2WDI4, N1PA12
    Conserved Domains (1) summary
    pfam10199
    Location:162 → 232
    Adaptin_binding; Alpha and gamma adaptin binding protein p34
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43615.1

Gene LinkOut

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