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KGD4 alpha-ketoglutarate dehydrogenase subunit KGD4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850610, updated on 18-Sep-2024

Summary

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Official Symbol
KGD4
Official Full Name
alpha-ketoglutarate dehydrogenase subunit KGD4
Primary source
SGD:S000001945
Locus tag
YFR049W
See related
AllianceGenome:SGD:S000001945; FungiDB:YFR049W; VEuPathDB:YFR049W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YMR31
Summary
A structural constituent of ribosome. Contributes to oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Located in mitochondrial ribosome. Part of mitochondrial oxoglutarate dehydrogenase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KGD4 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (248523..248894)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene nicotinate-nucleotide diphosphorylase (carboxylating) Neighboring gene Rmd8p Neighboring gene proteasome core particle subunit beta 7 Neighboring gene coatomer subunit delta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative Translation Initiation at a UUG Codon Gives Rise to Two Functional Variants of the Mitochondrial Protein Kgd4. Heublein M, et al. J Mol Biol, 2019 Mar 29. PMID 30822412
  2. Cloning and analysis of the nuclear genes for two mitochondrial ribosomal proteins in yeast. Matsushita Y, et al. Mol Gen Genet, 1989 Oct. PMID 2693936
  3. Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae. Eki T, et al. Yeast, 1996 Feb. PMID 8686379
  4. The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase. Heublein M, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165143, Free PMC Article
  5. N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae. Aksnes H, et al. PLoS One, 2013. PMID 23613772, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kgd4 is necessary for a stable incorporation of the E3 subunit into the E1-E2 core of yeast mitochondrial alpha-ketoglutarate dehydrogenase.
    Title: The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to oxoglutarate dehydrogenase (succinyl-transferring) activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to oxoglutarate dehydrogenase (succinyl-transferring) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 2-oxoglutarate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 2-oxoglutarate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-ketoglutarate dehydrogenase subunit KGD4
NP_116707.3
  • Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; exists in two forms derived from a single mRNA translated from two alternative start sites; evolutionarily conserved role in the organization of mitochondrial alpha-KGDH complexes; homolog of human KGD4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    248523..248894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180014.3 → NP_116707.3  TPA: alpha-ketoglutarate dehydrogenase subunit KGD4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116707.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTT2, P19955
    UniProtKB/TrEMBL
    A7A289, B3LUR0, C7GYF2, C8Z7Y4, G2WDJ0, N1P4S4
    Conserved Domains (1) summary
    pfam10937
    Location:16 → 122
    S36_mt; Ribosomal protein S36, mitochondrial
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19955.1

Gene LinkOut

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