YEH1 sterol esterase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YEH1
Official Full Name: sterol esterase
Primary source: SGD:S000003935
Locus tag: YLL012W
See related: AllianceGenome:SGD:S000003935; FungiDB:YLL012W; VEuPathDB:YLL012W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables sterol ester esterase activity. Involved in sterol metabolic process. Located in lipid droplet and membrane. Human ortholog(s) of this gene implicated in Wolman disease and cholesterol ester storage disease. Orthologous to human LIPA (lipase A, lysosomal acid type). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YEH1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (125534..127255)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study demonstrates a strong regulation of the two lipid droplet associated steryl ester hydrolases Tgl1p and Yeh1p due to the presence/absence of their host organelle.
Title: The impact of nonpolar lipids on the regulation of the steryl ester hydrolases Tgl1p and Yeh1p in the yeast Saccharomyces cerevisiae.
Yeh1 is the sole active steryl ester hydrolase under heme-deficient conditions, indicating that Yeh1 is activated whereas Yeh2 and Tgl1 are inactivated by the lack of heme.
Title: Yeh1 constitutes the major steryl ester hydrolase under heme-deficient conditions in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables sterol ester esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol ester esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol ester esterase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lipid droplet	HDA more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sterol esterase

NP_013089.1

EC 3.1.1.13

Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

125534..127255

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181832.1 → NP_013089.1 TPA: sterol esterase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013089.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXZ0, Q07804

UniProtKB/TrEMBL

G2WII3, N1P0A1

Conserved Domains (1) summary

PLN02872
Location:169 → 326

PLN02872; triacylglycerol lipase