COX17 copper metallochaperone COX17 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: COX17
Gene description: copper metallochaperone COX17
Primary source: FungiDB:YLL009C
Locus tag: YLL009C
See related: SGD:S000003932; AllianceGenome:SGD:S000003932; VEuPathDB:YLL009C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables copper chaperone activity. Involved in mitochondrial cytochrome c oxidase assembly and protein maturation by copper ion transfer. Located in cytosol and mitochondrial intermembrane space. Orthologous to human COX17 (cytochrome c oxidase copper chaperone COX17). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

propose that Cox17 is a newly identified factor involved in maintaining the architecture of the MICOS complex
Title: Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System.
These studies implicate different surfaces on Sco1 for interaction or function with Cox17 and Cox2.
Title: Mapping the functional interaction of Sco1 and Cox2 in cytochrome oxidase biogenesis.
Cysteine redox state is essential in modulating the structural and coper binding properties of Cox17.
Title: Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables copper chaperone activity	IBA Inferred from Biological aspect of Ancestor more info
enables copper chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables copper chaperone activity	IEA Inferred from Electronic Annotation more info
enables copper chaperone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial cytochrome c oxidase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation by copper ion transfer	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_013092.1

Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant