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BRE2 Bre2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850702, updated on 6-Oct-2024

Summary

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Official Symbol
BRE2
Official Full Name
Bre2p
Primary source
SGD:S000004005
Locus tag
YLR015W
See related
AllianceGenome:SGD:S000004005; FungiDB:YLR015W; VEuPathDB:YLR015W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CPS60
Summary
Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 trimethylation; subtelomeric heterochromatin assembly; and telomere maintenance. Part of Set1C/COMPASS complex. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BRE2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (175227..176744)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Gat3p Neighboring gene Ppr1p Neighboring gene Pml1p Neighboring gene S-methyl-5-thioadenosine phosphorylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TRAUCO, a Trithorax-group gene homologue, is required for early embryogenesis in Arabidopsis thaliana. Aquea F, et al. J Exp Bot, 2010 Feb. PMID 20118203, Free PMC Article
  2. A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. South PF, et al. J Biol Chem, 2010 Jan 1. PMID 19897479, Free PMC Article
  3. Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Hsu PL, et al. Cell, 2018 Aug 23. PMID 30100181, Free PMC Article
  4. Global study of holistic morphological effectors in the budding yeast Saccharomyces cerevisiae. Suzuki G, et al. BMC Genomics, 2018 Feb 20. PMID 29458326, Free PMC Article
  5. The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation. Choudhury R, et al. Genes Dev, 2019 May 1. PMID 30842216, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bre2 and Sdc1 are shown to directly interact, and it is shown that the association of this heteromeric complex is needed for proper H3K4 methylation and gene expression to occur.
    Title: A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone H3K4 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
  
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bre2p
NP_013115.1
  • Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    175227..176744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181902.1 → NP_013115.1  TPA: Bre2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY17, E9PA88, P43132
    UniProtKB/TrEMBL
    B3LSY8, C8ZCY7
    Conserved Domains (1) summary
    cd12872
    Location:101 → 244
    SPRY_Ash2; SPRY domain in Ash2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43132.2

Gene LinkOut

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