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MEF1 Mef1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850758, updated on 28-Oct-2024

Summary

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Official Symbol
MEF1
Official Full Name
Mef1p
Primary source
SGD:S000004059
Locus tag
YLR069C
See related
AllianceGenome:SGD:S000004059; FungiDB:YLR069C; VEuPathDB:YLR069C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable GTPase activity and translation elongation factor activity. Involved in mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See MEF1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (271630..273915, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pet309p Neighboring gene Fyv7p Neighboring gene D-xylulose reductase XYL2 Neighboring gene Rgr1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of elongation factor G as the conserved cellular target of argyrin B. Nyfeler B, et al. PLoS One, 2012. PMID 22970117, Free PMC Article
  2. Mitochondrial translational-initiation and elongation factors in Saccharomyces cerevisiae. Vambutas A, et al. Eur J Biochem, 1991 Nov 1. PMID 1935960
  3. A quantitative yeast aging proteomics analysis reveals novel aging regulators. Sun Y, et al. Geroscience, 2021 Oct. PMID 34241809, Free PMC Article
  4. Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. Valente L, et al. Am J Hum Genet, 2007 Jan. PMID 17160893, Free PMC Article
  5. Regulation of Saccharomyces cerevisiae MEF1 by Hda1p affects salt resistance of bdf1Δ mutant. Chen L, et al. FEMS Yeast Res, 2014 Jun. PMID 25035869

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggested that Bdf1p likely regulated MEF1 expression negatively by regulating HDA1 positively
    Title: Regulation of Saccharomyces cerevisiae MEF1 by Hda1p affects salt resistance of bdf1Δ mutant.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translational elongation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Mef1p
NP_013170.1
  • Mitochondrial elongation factor involved in translational elongation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    271630..273915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181956.1 → NP_013170.1  TPA: Mef1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013170.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY70, P25039, Q6B1Y6, Q99360
    UniProtKB/TrEMBL
    G2WIR1, N1P6E7
    Conserved Domains (1) summary
    COG0480
    Location:68 → 760
    FusA; Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25039.2

Gene LinkOut

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