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BUD20 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850763, updated on 22-Aug-2024

Summary

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Official Symbol
BUD20
Primary source
FungiDB:YLR074C
Locus tag
YLR074C
See related
SGD:S000004064; AllianceGenome:SGD:S000004064; VEuPathDB:YLR074C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ribosomal large subunit binding activity. Involved in ribosomal large subunit export from nucleus. Located in cytoplasm and nucleus. Part of preribosome, large subunit precursor. Orthologous to human ZNF593 (zinc finger protein 593). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BUD20 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (281956..282456, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Lam6p Neighboring gene Rfu1p Neighboring gene ribosomal 60S subunit protein L10 Neighboring gene Fmp25p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes. Olombrada M, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32365182, Free PMC Article
  2. The L1 stalk is required for efficient export of nascent large ribosomal subunits in yeast. Musalgaonkar S, et al. RNA, 2019 Nov. PMID 31439809, Free PMC Article
  3. The genomic landscape of compensatory evolution. Szamecz B, et al. PLoS Biol, 2014 Aug. PMID 25157590, Free PMC Article
  4. Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly. Micic J, et al. Nat Commun, 2020 Jul 27. PMID 32719344, Free PMC Article
  5. Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Zhou Y, et al. Nat Commun, 2019 Feb 27. PMID 30814529, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal large subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in ribosomal large subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bud20p
NP_013175.1
  • C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    281956..282456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181961.1 → NP_013175.1  TPA: Bud20p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013175.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY75, Q08004
    UniProtKB/TrEMBL
    C7GQP9, G2WIR6, N1P6F1
    Conserved Domains (1) summary
    COG5112
    Location:1 → 133
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08004.1

Gene LinkOut

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