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EMP70 Emp70p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850772, updated on 2-Nov-2024

Summary

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Official Symbol
EMP70
Official Full Name
Emp70p
Primary source
SGD:S000004073
Locus tag
YLR083C
See related
AllianceGenome:SGD:S000004073; FungiDB:YLR083C; VEuPathDB:YLR083C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TMN1
Summary
Involved in several processes, including intracellular copper ion homeostasis; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in endosome and fungal-type vacuole membrane. Orthologous to several human genes including TM9SF2 (transmembrane 9 superfamily member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See EMP70 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (294091..296094, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene galactose permease GAL2 Neighboring gene Srl2p Neighboring gene Rax2p Neighboring gene Arp6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Partial purification and characterization of early and late endosomes from yeast. Identification of four novel proteins. Singer-Krüger B, et al. J Biol Chem, 1993 Jul 5. PMID 8314797
  2. Conserved function of the lysine-based KXD/E motif in Golgi retention for endomembrane proteins among different organisms. Woo CH, et al. Mol Biol Cell, 2015 Nov 15. PMID 26378254, Free PMC Article
  3. Transmembrane nine proteins in yeast and Arabidopsis affect cellular metal contents without changing vacuolar morphology. Hegelund JN, et al. Physiol Plant, 2010 Dec. PMID 20681974
  4. Characterization of a 76 kDa endosomal, multispanning membrane protein that is highly conserved throughout evolution. Schimmöller F, et al. Gene, 1998 Aug 31. PMID 9729438
  5. Control of cellular physiology by TM9 proteins in yeast and Dictyostelium. Froquet R, et al. J Biol Chem, 2008 Mar 14. PMID 18178563

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosomal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular copper ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular monoatomic cation homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pseudohyphal growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vacuolar transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Emp70p
NP_013184.1
  • Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    294091..296094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181970.1 → NP_013184.1  TPA: Emp70p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013184.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY83, P32802, Q12101
    UniProtKB/TrEMBL
    A7A0Y7, B3LT51, C7GQQ7
    Conserved Domains (1) summary
    pfam02990
    Location:72 → 624
    EMP70; Endomembrane protein 70
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32802.2

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