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RAX2 Rax2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850773, updated on 2-Nov-2024

Summary

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Official Symbol
RAX2
Official Full Name
Rax2p
Primary source
SGD:S000004074
Locus tag
YLR084C
See related
AllianceGenome:SGD:S000004074; FungiDB:YLR084C; VEuPathDB:YLR084C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in axial cellular bud site selection; bipolar cellular bud site selection; and protein localization. Located in cellular bud neck and cellular bud scar. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RAX2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (296589..300251, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Srl2p Neighboring gene Emp70p Neighboring gene Arp6p Neighboring gene condensin subunit SMC4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A three-hybrid screen identifies mRNAs controlled by a regulatory protein. Seay D, et al. RNA, 2006 Aug. PMID 16809817, Free PMC Article
  2. Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast. Chen T, et al. Science, 2000 Dec 8. PMID 11110666
  3. Subcellular localization of the interaction of bipolar landmarks Bud8p and Bud9p with Rax2p in Saccharomyces cerevisiae diploid cells. Kato Y, et al. Biochem Biophys Res Commun, 2010 Sep 3. PMID 20678480
  4. Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast. Kang PJ, et al. Mol Biol Cell, 2004 Nov. PMID 15356260, Free PMC Article
  5. Translational repression by PUF proteins in vitro. Chritton JJ, et al. RNA, 2010 Jun. PMID 20427513, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These observations suggest that the interaction of Rax2p with Bud8p and Bud9p may contribute to the translocation of bipolar landmarks to the correct sites.
    Title: Subcellular localization of the interaction of bipolar landmarks Bud8p and Bud9p with Rax2p in Saccharomyces cerevisiae diploid cells.
  2. Rax1p and Rax2p interact closely with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical landmarks for bipolar budding
    Title: Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bipolar cellular bud site selection IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in bipolar cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular bud site selection IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
is_active_in cellular bud neck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular bud scar IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud scar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane of growing cell tip IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rax2p
NP_013185.1
  • Protein required for the maintenance of bud site selection; localizes; localization to the bud neck and previous sites of cell division (bud scars; cytokinesis remnants (CRMs)) is interdependent with Rax2p; required with Rax1p to anchor both Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established preventing repolarization of cells at previous division sites; RAX2 mRNA stability is regulated by Mpt5p; predicted type I membrane-spanning protein; N-glycosylated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    296589..300251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181971.1 → NP_013185.1  TPA: Rax2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013185.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY84, Q12465
    UniProtKB/TrEMBL
    A7A0Y8, B3LT52, B5VN16
    Conserved Domains (1) summary
    pfam12768
    Location:976 → 1213
    Rax2; Cortical protein marker for cell polarity
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12465.1

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