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IOC2 Ioc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850784, updated on 18-Sep-2024

Summary

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Official Symbol
IOC2
Official Full Name
Ioc2p
Primary source
SGD:S000004085
Locus tag
YLR095C
See related
AllianceGenome:SGD:S000004085; FungiDB:YLR095C; VEuPathDB:YLR095C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to ATP hydrolysis activity; DNA binding activity; and nucleosome binding activity. Involved in chromatin remodeling. Part of Isw1b complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IOC2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (329677..332115, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Nyv1p Neighboring gene Gis3p Neighboring gene serine/threonine protein kinase KIN2 Neighboring gene SCF ubiquitin ligase complex subunit HRT3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isw1 acts independently of the Isw1a and Isw1b complexes in regulating transcriptional silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Mueller JE, et al. J Mol Biol, 2007 Aug 3. PMID 17561109, Free PMC Article
  2. Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention. Matabishi-Bibi L, et al. Nat Commun, 2022 Oct 25. PMID 36284099, Free PMC Article
  3. Dependency of ISW1a chromatin remodeling on extranucleosomal DNA. Gangaraju VK, et al. Mol Cell Biol, 2007 Apr. PMID 17283061, Free PMC Article
  4. Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes. Stockdale C, et al. J Biol Chem, 2006 Jun 16. PMID 16606615, Free PMC Article
  5. Yeast Isw1p forms two separable complexes in vivo. Vary JC Jr, et al. Mol Cell Biol, 2003 Jan. PMID 12482963, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Isw1b complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ioc2p
NP_013196.1
  • Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    329677..332115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181982.1 → NP_013196.1  TPA: Ioc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013196.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY95, Q12072
    UniProtKB/TrEMBL
    A7A0Z9, N1P134
    Conserved Domains (1) summary
    cl22851
    Location:556 → 584
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12072.1

Gene LinkOut

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