SEN2 tRNA splicing endonuclease subunit SEN2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEN2
Official Full Name: tRNA splicing endonuclease subunit SEN2
Primary source: SGD:S000004095
Locus tag: YLR105C
See related: AllianceGenome:SGD:S000004095; FungiDB:YLR105C; VEuPathDB:YLR105C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables tRNA-intron endonuclease activity. Involved in mRNA cleavage involved in mRNA processing and tRNA-type intron splice site recognition and cleavage. Located in mitochondrial outer membrane. Part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEN2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (347047..348180, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables tRNA-intron endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-intron endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA-intron endonuclease activity	IEA Inferred from Electronic Annotation more info
enables tRNA-intron endonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in tRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	IEA Inferred from Electronic Annotation more info
involved_in tRNA-type intron splice site recognition and cleavage	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA-type intron splice site recognition and cleavage	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA-type intron splice site recognition and cleavage	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in peroxisome	HDA more info	PubMed
part_of tRNA-intron endonuclease complex	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA-intron endonuclease complex	IDA Inferred from Direct Assay more info	PubMed
part_of tRNA-intron endonuclease complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA splicing endonuclease subunit SEN2

NP_013206.1

EC 4.6.1.16

Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; localizes to the peroxisome in a Pex5p-dependent manner in oleate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

347047..348180 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181992.1 → NP_013206.1 TPA: tRNA splicing endonuclease subunit SEN2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013206.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYA5, P16658

UniProtKB/TrEMBL

A7A109, B3LT73, C7GQS8, C8ZD76, G2WIU8, N1NZ86

Conserved Domains (2) summary

TIGR00324
Location:171 → 343

endA; tRNA-intron lyase

cl12013
Location:137 → 185

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature