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CCW12 Ccw12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850800, updated on 18-Sep-2024

Summary

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Official Symbol
CCW12
Official Full Name
Ccw12p
Primary source
SGD:S000004100
Locus tag
YLR110C
See related
AllianceGenome:SGD:S000004100; FungiDB:YLR110C; VEuPathDB:YLR110C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in agglutination involved in conjugation with cellular fusion and fungal-type cell wall organization. Located in cellular bud tip; fungal-type cell wall; and mating projection tip. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CCW12 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (369697..370098, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene thioredoxin peroxidase AHP1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping HA-tagged protein at the surface of living cells by atomic force microscopy. Formosa C, et al. J Mol Recognit, 2015 Jan. PMID 26046654
  2. Characterization of Ccw12p, a major key player in cell wall stability of Saccharomyces cerevisiae. Ragni E, et al. Yeast, 2007 Apr. PMID 17315267
  3. Improving the functionality of surface-engineered yeast cells by altering the cell wall morphology of the host strain. Inokuma K, et al. Appl Microbiol Biotechnol, 2021 Aug. PMID 34272577
  4. Characterization of two new genes down-regulated by alpha-factor. Seidel J, et al. Yeast, 1997 Jul. PMID 9234669
  5. Cargo crowding contributes to sorting stringency in COPII vesicles. Gomez-Navarro N, et al. J Cell Biol, 2020 Jul 6. PMID 32406500, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ccw12p is necessary to ensure cell wall integrity, especially during bud emergence and formation of the mating projection.
    Title: The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections.
  2. Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein.
    Title: Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein.
  3. major role in cell wall stability.
    Title: Characterization of Ccw12p, a major key player in cell wall stability of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of cell wall IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in agglutination involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ccw12p
NP_013211.1
  • Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    369697..370098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181997.1 → NP_013211.1  TPA: Ccw12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013211.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYB0, Q12127
    UniProtKB/TrEMBL
    A7A114, B3LT77, C7GQT2, C8ZD81, G2WIV4, N1NY69
    Conserved Domains (1) summary
    pfam13928
    Location:32 → 75
    Flocculin_t3; Flocculin type 3 repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12127.1

Gene LinkOut

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