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YPS1 aspartyl protease [ Saccharomyces cerevisiae S288C ]

Gene ID: 850811, updated on 18-Sep-2024

Summary

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Official Symbol
YPS1
Official Full Name
aspartyl protease
Primary source
SGD:S000004110
Locus tag
YLR120C
See related
AllianceGenome:SGD:S000004110; FungiDB:YLR120C; VEuPathDB:YLR120C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YAP3
Summary
Enables aspartic-type endopeptidase activity. Involved in fungal-type cell wall organization; protein maturation; and signal transduction involved in filamentous growth. Is anchored component of plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension (multiple); and portal hypertension. Orthologous to human BACE2 (beta-secretase 2) and REN (renin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YPS1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (386511..388220, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene palmitoyl-(protein) hydrolase Neighboring gene ESCRT-I subunit protein SRN2 Neighboring gene aspartyl protease Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yapsin 1 immunoreactivity in {alpha}-cells of human pancreatic islets: implications for the processing of human proglucagon by mammalian aspartic proteases. Cawley NX, et al. J Endocrinol, 2011 Aug. PMID 21632904, Free PMC Article
  2. Proteolytic function of GPI-anchored plasma membrane protease Yps1p in the yeast vacuole and Golgi. Sievi E, et al. Traffic, 2001 Dec. PMID 11737827
  3. Production of full-length human pre-elafin, an elastase specific inhibitor, from yeast requires the absence of a functional yapsin 1 (Yps1p) endoprotease. Bourbonnais Y, et al. Protein Expr Purif, 2000 Dec. PMID 11087688
  4. Yield improvement of heterologous peptides expressed in yps1-disrupted Saccharomyces cerevisiae strains. Egel-Mitani M, et al. Enzyme Microb Technol, 2000 Jun 1. PMID 10862872
  5. Proteolytic stability of recombinant human serum albumin secreted in the yeast Saccharomyces cerevisiae. Kang HA, et al. Appl Microbiol Biotechnol, 2000 May. PMID 10855718

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yps1 N-entrance loop plays a major role in regulating the shedding activity of the endopeptidase, most likely by limiting access to the active site, and its cleavage in native Yps1 is associated with its shedding.
    Title: N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase.
  2. The activation mechanism of GPI-anchored Yps1p was investigated and some of its substrates were identified.
    Title: Activation mechanism, functional role and shedding of glycosylphosphatidylinositol-anchored Yps1p at the Saccharomyces cerevisiae cell surface.
  3. Saccharomyces cerevisiae mucin Msb2p is processed into secreted and cell-associated forms, by the aspartyl protease Yps1p.
    Title: Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast.
  4. YPS1 expression is induced during cell wall stress and remodeling in a PKC1-MPK1-dependent manner, indicating that Yps1p is a direct, and important, output of the cell wall integrity response
    Title: Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction involved in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartyl protease
NP_013221.1
  • Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    386511..388220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182007.1 → NP_013221.1  TPA: aspartyl protease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013221.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYB8, P32329, Q12419
    UniProtKB/TrEMBL
    A7A122, B3LT84, B5VN55, C7GQD2, C8ZD89, G2WIW2, N1NZA6
    Conserved Domains (1) summary
    cd05474
    Location:81 → 477
    SAP_like; SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32329.2

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