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SEC10 exocyst subunit SEC10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850863, updated on 2-Nov-2024

Summary

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Official Symbol
SEC10
Official Full Name
exocyst subunit SEC10
Primary source
SGD:S000004156
Locus tag
YLR166C
See related
AllianceGenome:SGD:S000004156; FungiDB:YLR166C; VEuPathDB:YLR166C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in Golgi to plasma membrane transport and exocytosis. Located in cellular bud neck and mating projection tip. Part of exocyst. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SEC10 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (495429..498044, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene protein SHH4 Neighboring gene pseudouridine synthase PUS5 Neighboring gene ubiquitin-ribosomal 40S subunit protein S31 fusion protein Neighboring gene Ups2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. Lipschutz JH, et al. Mol Biol Cell, 2000 Dec. PMID 11102522, Free PMC Article
  2. Conservation of helical bundle structure between the exocyst subunits. Croteau NJ, et al. PLoS One, 2009. PMID 19214222, Free PMC Article
  3. Exo84p is an exocyst protein essential for secretion. Guo W, et al. J Biol Chem, 1999 Aug 13. PMID 10438536
  4. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. TerBush DR, et al. J Cell Biol, 1995 Jul. PMID 7615633, Free PMC Article
  5. The rab exchange factor Sec2p reversibly associates with the exocyst. Medkova M, et al. Mol Biol Cell, 2006 Jun. PMID 16611746, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip HDA PubMed 

General protein information

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Preferred Names
exocyst subunit SEC10
NP_013267.1
  • Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    495429..498044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182053.1 → NP_013267.1  TPA: exocyst subunit SEC10 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013267.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYH2, P87329, Q06245
    UniProtKB/TrEMBL
    A7A159, B5VN85, C7GIV8, C8ZDD9, G2WJ01
    Conserved Domains (1) summary
    pfam07393
    Location:120 → 858
    Sec10; Exocyst complex component Sec10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06245.1

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