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TOS4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850880, updated on 22-Aug-2024

Summary

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Official Symbol
TOS4
Primary source
FungiDB:YLR183C
Locus tag
YLR183C
See related
SGD:S000004173; AllianceGenome:SGD:S000004173; VEuPathDB:YLR183C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chromatin binding activity. Involved in cellular response to DNA damage stimulus and regulation of gene expression. Located in chromatin and nucleus. Part of Rpd3L-Expanded complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TOS4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (520543..522012, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Vta1p Neighboring gene transcriptional regulator SWI6 Neighboring gene ribosomal 60S subunit protein L37A Neighboring gene 18S rRNA pseudouridine methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tos4 mediates gene expression homeostasis through interaction with HDAC complexes independently of H3K56 acetylation. Cooke SL, et al. J Biol Chem, 2021 Jan-Jun. PMID 33713703, Free PMC Article
  2. Expression homeostasis during DNA replication. Voichek Y, et al. Science, 2016 Mar 4. PMID 26941319
  3. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Tu BP, et al. Science, 2005 Nov 18. PMID 16254148
  4. A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations. Lemon LD, et al. G3 (Bethesda), 2022 Jul 6. PMID 35567477, Free PMC Article
  5. Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes. Bastos de Oliveira FM, et al. EMBO J, 2012 Apr 4. PMID 22333912, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rpd3L-Expanded complex HDA PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tos4p
NP_013284.1
  • Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    520543..522012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182070.1 → NP_013284.1  TPA: Tos4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013284.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYI7, Q06266
    UniProtKB/TrEMBL
    A7A174, C7GIX2, G2WJ16, N1NZD4
    Conserved Domains (1) summary
    cd00060
    Location:113 → 172
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06266.1

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