ATG26 sterol 3-beta-glucosyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATG26
Official Full Name: sterol 3-beta-glucosyltransferase
Primary source: SGD:S000004179
Locus tag: YLR189C
See related: AllianceGenome:SGD:S000004179; FungiDB:YLR189C; VEuPathDB:YLR189C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: UGT51
Summary: Enables sterol 3-beta-glucosyltransferase activity. Involved in ascospore-type prospore membrane formation and sterol metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ATG26 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (530797..534393, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ordered Coimmobilization of Multimeric Enzyme Arrays with Enhanced Biocatalytic Cascade Performance.
Title: Ordered Coimmobilization of Multimeric Enzyme Arrays with Enhanced Biocatalytic Cascade Performance.
The structural analysis indicate that a long hydrophobic cavity, 9.2A in width and 17.6A in length located at the N-terminal domain of sterol glycosyltransferase UGT51, is suitable for the accommodation of sterol acceptor substrates.
Title: Structural dissection of sterol glycosyltransferase UGT51 from Saccharomyces cerevisiae for substrate specificity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables UDP-glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sterol 3-beta-glucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol 3-beta-glucosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ascospore-type prospore membrane formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid glycosylation	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sterol 3-beta-glucosyltransferase

NP_013290.1

EC 2.4.1.173

UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

530797..534393 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182076.1 → NP_013290.1 TPA: sterol 3-beta-glucosyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013290.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYJ2, Q06321

UniProtKB/TrEMBL

B3RH80, B5VNA8, C7GIX6, N1NZD7

Conserved Domains (4) summary

smart00568
Location:194 → 239

GRAM; domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins

COG1819
Location:739 → 1168

YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]

cd13215
Location:219 → 335

PH-GRAM1_AGT26; Autophagy-related protein 26/Sterol 3-beta-glucosyltransferase Pleckstrin homology (PH) domain, repeat 1

cd13216
Location:581 → 673

PH-GRAM2_AGT26; Autophagy-related protein 26/Sterol 3-beta-glucosyltransferase Pleckstrin homology (PH) domain, repeat 2