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PWP1 rRNA-processing protein PWP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850893, updated on 18-Sep-2024

Summary

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Official Symbol
PWP1
Official Full Name
rRNA-processing protein PWP1
Primary source
SGD:S000004186
Locus tag
YLR196W
See related
AllianceGenome:SGD:S000004186; FungiDB:YLR196W; VEuPathDB:YLR196W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in rRNA processing. Located in cytoplasm and nucleolus. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PWP1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (543968..545698)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ncw2p Neighboring gene glycylpeptide N-tetradecanoyltransferase NMT1 Neighboring gene snoRNP complex protein NOP56 Neighboring gene Pba1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1. Duronio RJ, et al. Proteins, 1992 May. PMID 1594577
  2. The WD40-repeat protein Pwp1p associates in vivo with 25S ribosomal chromatin in a histone H4 tail-dependent manner. Suka N, et al. Nucleic Acids Res, 2006. PMID 16855292, Free PMC Article
  3. The functional landscape of mouse gene expression. Zhang W, et al. J Biol, 2004. PMID 15588312, Free PMC Article
  4. Cloning of a cDNA encoding a novel human nuclear phosphoprotein belonging to the WD-40 family. Honoré B, et al. Gene, 1994 Dec 30. PMID 7828893
  5. Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control. Meydan S, et al. Mol Cell, 2020 Aug 20. PMID 32615089, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Misfolded pre-rRNAs are stable in the absence of Nop12 but rapidly turned over when Pwp1 is not present.
    Title: Ribosome assembly factors Pwp1 and Nop12 are important for folding of 5.8S rRNA during ribosome biogenesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleolus HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rRNA-processing protein PWP1
NP_013297.1
  • Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    543968..545698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182083.1 → NP_013297.1  TPA: rRNA-processing protein PWP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYJ9, P21304
    UniProtKB/TrEMBL
    A7A186, B3RH87, C7GIS8, N1NZT2
    Conserved Domains (2) summary
    COG2319
    Location:280 → 554
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:289 → 327
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21304.1

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