YKE2 tubulin-binding prefolding complex subunit YKE2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YKE2
Official Full Name: tubulin-binding prefolding complex subunit YKE2
Primary source: SGD:S000004190
Locus tag: YLR200W
See related: AllianceGenome:SGD:S000004190; FungiDB:YLR200W; VEuPathDB:YLR200W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GIM1; PFD6
Summary: Enables tubulin binding activity. Involved in positive regulation of transcription elongation by RNA polymerase II; protein folding; and tubulin complex assembly. Located in cytoplasm. Part of prefoldin complex. Orthologous to human PFDN6 (prefoldin subunit 6). [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tubulin complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of prefoldin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	IEA Inferred from Electronic Annotation more info
part_of prefoldin complex	IPI Inferred from Physical Interaction more info	PubMed

NP_013301.1

Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation

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The following sections contain reference sequences that belong to a specific genome build. Explain